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- W2022227140 abstract "Calcineurin is a Ca(2+)/calmodulin-activated protein phosphatase that is conserved in eukaryotes, from yeast to humans, and is the conserved target of the immunosuppressive drugs cyclosporin A (CsA) and FK506. Genetic studies in yeast and fungi established the molecular basis of calcineurin inhibition by the cyclophilin A-CsA and FKBP12-FK506 complexes. Calcineurin also functions in fungi to control a myriad of physiological processes including cell cycle progression, cation homeostasis, and morphogenesis. Recent investigations into the molecular mechanisms of pathogenesis in Candida albicans and Cryptococcus neoformans, two fungi that cause life-threatening infections in humans, have revealed an essential role for calcineurin in morphogenesis, virulence, and antifungal drug action. Novel non-immunosuppressive analogs of the calcineurin inhibitors CsA and FK506 that retain antifungal activity have been identified and hold promise as candidate antifungal drugs. In addition, comparisons of calcineurin function in both fungi and humans may identify fungal-specific components of calcineurin-signaling pathways that could be targeted for therapy, as well as conserved elements of calcium signaling events." @default.
- W2022227140 created "2016-06-24" @default.
- W2022227140 creator A5045916438 @default.
- W2022227140 creator A5052159588 @default.
- W2022227140 date "2002-09-25" @default.
- W2022227140 modified "2023-10-15" @default.
- W2022227140 title "Good fungi gone bad: The corruption of calcineurin" @default.
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- W2022227140 doi "https://doi.org/10.1002/bies.10157" @default.
- W2022227140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12325122" @default.
- W2022227140 hasPublicationYear "2002" @default.
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