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• W2022227212 abstract "The interaction of 5 alpha-dihydrotestosterone-receptor complexes with purified DNA fragments representing upstream, coding and intervening sequences of the prostate binding protein C3(1) gene was investigated using a DNA-cellulose competition binding assay. The partially purified androgen-receptor complexes which were used in the assay had proven DNA-binding capabilities. Two fragments were identified with relatively high affinity for androgen-receptor complexes. A 300 bp fragment extending from -220 to +80 and a 500 bp fragment derived entirely from the first intron consistently competed most effectively in the system. The presence of a high affinity site or sites in or near the promoter region of the gene is consistent with current models of transcriptional activation of hormone-responsive genes by steroid receptors. High affinity sites for steroid receptors within introns may indicate a role for receptors in regulation of transcription at other stages, or in post-transcriptional modification." @default.
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• W2022227212 date "1987-06-01" @default.
• W2022227212 modified "2023-09-25" @default.
• W2022227212 title "Androgen receptor-binding regions of an androgen-responsive gene" @default.
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• W2022227212 doi "https://doi.org/10.1016/0303-7207(87)90036-0" @default.
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