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• W2022228423 startingPage "129" @default.
• W2022228423 abstract "The role of vascular endothelial growth factor (VEGF) on cathepsin L expression was investigated in human glioblastoma cells (U87MG). Our results demonstrate the transcriptional upregulation of cathepsin L expression by VEGF. Transient transfection of U87MG cells with VEGF expression vector significantly increased cathepsin L activity. These results were further corroborated by a parallel increase in the mRNA levels and promoter activity of cathepsin L by VEGF. By deletion analysis, we identified a 47 base pair VEGF response element (VRE) in human cathepsin L promoter. Site directed mutagenesis studies demonstrated that both SP-1 and AP-4 motifs present in this region contribute to VEGF responsiveness. These results prove for the first time that over-expression of VEGF in human glioblastoma cells induces cathepsin L expression at the transcriptional level. This mechanism could be involved in the enhanced tumorogenic potential of these cells." @default.
• W2022228423 created "2016-06-24" @default.
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• W2022228423 date "2007-09-01" @default.
• W2022228423 modified "2023-09-29" @default.
• W2022228423 title "Transcriptional upregulation of human cathepsin L by VEGF in glioblastoma cells" @default.
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• W2022228423 doi "https://doi.org/10.1016/j.gene.2007.05.002" @default.
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