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• W2022229181 abstract "Active solute transport mediated by molecular motors across porous membranes is a well-recognized mechanism for transport across the cell membrane. In contrast, active transport mediated by mechanical loading of porous media is a non-intuitive mechanism that has only been predicted recently from theory, but not yet observed experimentally. This study uses agarose hydrogel and dextran molecules as a model experimental system to explore this mechanism. Results show that dynamic loading can enhance the uptake of dextran by a factor greater than 15 over passive diffusion, for certain combinations of gel concentration and dextran molecular weight. Upon cessation of loading, the concentration reverts back to that achieved under passive diffusion. Thus, active solute transport in porous media can indeed be mediated by cyclical mechanical loading." @default.
• W2022229181 created "2016-06-24" @default.
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• W2022229181 date "2008-11-01" @default.
• W2022229181 modified "2023-10-02" @default.
• W2022229181 title "Dynamic loading of deformable porous media can induce active solute transport" @default.
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• W2022229181 doi "https://doi.org/10.1016/j.jbiomech.2008.08.023" @default.
• W2022229181 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2633098" @default.
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