FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022229519> ?p ?o ?g. }

• W2022229519 endingPage "354" @default.
• W2022229519 startingPage "345" @default.
• W2022229519 abstract "Background: Candidemia is fourfold more common in 1990 compared to 1980. In addition, a shift to non-albicans species has occurred in some institutions. Antifungal prophylaxis (AP) is effective in high-risk patients including critically ill surgical patients, but its use has been attributed to a resultant shift to non-albicans candida species. We hypothesized that the use of fluconazole prophylaxis would lead to a decreased incidence of candidemia but a possible increased incidence of resistant species of Candida, especially Candida glabrata (CG). Methods: From 1990 to 2002, all patients with candidemia (C) in the surgical intensive care unit (SICU) of a large tertiary care hospital were identified and reviewed retrospectively. Antifungal prophylaxis began in 2000 for high-risk patients. The periods were separated into PRE (1990-2000), and POST prophylaxis (2000-2002). Results: Excluding the year of the trial studying prophylaxis, (1998; five cases of C) a total of 83 patients developed candidemia: 69 PRE (83%) (1.94/1000 patient days) and 14 POST (17%) (0.76/1000 patient days) (OR 0.44; 95% CI 0.25, 0.78; p = 0.004). In the PRE period C. albicans (45%) and CG (30%) were predominant, whereas in the POST period, CG (9/14, 64%) (p = 0.05), and C. albicans (3/14, 21%) were common. Non-albicans species were 38/69 (55%) PRE and 11/14 (79%) POST, p = 0.14. Mortality in the group was 43/83 (52%) and did not differ PRE/POST or based on treatment. Predictors of SICU mortality (model r2 = 0.61) included hospital length of stay (LOS) (OR 1.14, CI 1.04, 1.25), fever (OR 51.2, CI 2.46, 1064), and broad-spectrum antibiotics (OR 69.7, CI 2.08, 2351), whereas post-transplantation status (OR 0.005, CI 0.00, 0.56), blood sugar <180 mg/dL (OR 0.03, CI 0.01, 0.81), and fungal prophylaxis (OR 0.03, CI 0.01, 0.58) were associated with a decreased risk of mortality. Conclusions: Unfortunately, the mortality of candidemia remains high in SICU patients (52%). In the SICU, risk factors for candidemia and mortality are common. However, antifungal prophylaxis has significantly decreased the annual incidence of candidemia without a statistically significant shift to non-albicans pathogens." @default.
• W2022229519 created "2016-06-24" @default.
• W2022229519 creator A5002473571 @default.
• W2022229519 creator A5029586787 @default.
• W2022229519 creator A5041623915 @default.
• W2022229519 date "2003-12-01" @default.
• W2022229519 modified "2023-09-25" @default.
• W2022229519 title "Candidemia: The Impact of Antifungal Prophylaxis in a Surgical Intensive Care Unit" @default.
• W2022229519 cites W1666861259 @default.
• W2022229519 cites W172096228 @default.
• W2022229519 cites W1899514055 @default.
• W2022229519 cites W1968255503 @default.
• W2022229519 cites W1969836778 @default.
• W2022229519 cites W1979297402 @default.
• W2022229519 cites W2004434620 @default.
• W2022229519 cites W2013094738 @default.
• W2022229519 cites W2018879230 @default.
• W2022229519 cites W2021442034 @default.
• W2022229519 cites W2051586681 @default.
• W2022229519 cites W2061748969 @default.
• W2022229519 cites W2064433762 @default.
• W2022229519 cites W2064476714 @default.
• W2022229519 cites W2067454133 @default.
• W2022229519 cites W2071756060 @default.
• W2022229519 cites W2081823113 @default.
• W2022229519 cites W2099975106 @default.
• W2022229519 cites W2105124717 @default.
• W2022229519 cites W2113338279 @default.
• W2022229519 cites W2121025359 @default.
• W2022229519 cites W2149806222 @default.
• W2022229519 cites W2158730440 @default.
• W2022229519 cites W2169453316 @default.
• W2022229519 cites W2339375844 @default.
• W2022229519 cites W2341266869 @default.
• W2022229519 cites W4252423093 @default.
• W2022229519 doi "https://doi.org/10.1089/109629603322761409" @default.
• W2022229519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15012861" @default.
• W2022229519 hasPublicationYear "2003" @default.
• W2022229519 type Work @default.
• W2022229519 sameAs 2022229519 @default.
• W2022229519 citedByCount "52" @default.
• W2022229519 countsByYear W20222295192012 @default.
• W2022229519 countsByYear W20222295192014 @default.
• W2022229519 countsByYear W20222295192015 @default.
• W2022229519 countsByYear W20222295192016 @default.
• W2022229519 countsByYear W20222295192021 @default.
• W2022229519 countsByYear W20222295192022 @default.
• W2022229519 countsByYear W20222295192023 @default.
• W2022229519 crossrefType "journal-article" @default.
• W2022229519 hasAuthorship W2022229519A5002473571 @default.
• W2022229519 hasAuthorship W2022229519A5029586787 @default.
• W2022229519 hasAuthorship W2022229519A5041623915 @default.
• W2022229519 hasConcept C120665830 @default.
• W2022229519 hasConcept C121332964 @default.
• W2022229519 hasConcept C126322002 @default.
• W2022229519 hasConcept C141071460 @default.
• W2022229519 hasConcept C145081991 @default.
• W2022229519 hasConcept C16005928 @default.
• W2022229519 hasConcept C2776376669 @default.
• W2022229519 hasConcept C2779548794 @default.
• W2022229519 hasConcept C2780558435 @default.
• W2022229519 hasConcept C2780651595 @default.
• W2022229519 hasConcept C2780670043 @default.
• W2022229519 hasConcept C2780908437 @default.
• W2022229519 hasConcept C2780917455 @default.
• W2022229519 hasConcept C61511704 @default.
• W2022229519 hasConcept C71924100 @default.
• W2022229519 hasConcept C86803240 @default.
• W2022229519 hasConcept C89423630 @default.
• W2022229519 hasConceptScore W2022229519C120665830 @default.
• W2022229519 hasConceptScore W2022229519C121332964 @default.
• W2022229519 hasConceptScore W2022229519C126322002 @default.
• W2022229519 hasConceptScore W2022229519C141071460 @default.
• W2022229519 hasConceptScore W2022229519C145081991 @default.
• W2022229519 hasConceptScore W2022229519C16005928 @default.
• W2022229519 hasConceptScore W2022229519C2776376669 @default.
• W2022229519 hasConceptScore W2022229519C2779548794 @default.
• W2022229519 hasConceptScore W2022229519C2780558435 @default.
• W2022229519 hasConceptScore W2022229519C2780651595 @default.
• W2022229519 hasConceptScore W2022229519C2780670043 @default.
• W2022229519 hasConceptScore W2022229519C2780908437 @default.
• W2022229519 hasConceptScore W2022229519C2780917455 @default.
• W2022229519 hasConceptScore W2022229519C61511704 @default.
• W2022229519 hasConceptScore W2022229519C71924100 @default.
• W2022229519 hasConceptScore W2022229519C86803240 @default.
• W2022229519 hasConceptScore W2022229519C89423630 @default.
• W2022229519 hasIssue "4" @default.
• W2022229519 hasLocation W20222295191 @default.
• W2022229519 hasLocation W20222295192 @default.
• W2022229519 hasOpenAccess W2022229519 @default.
• W2022229519 hasPrimaryLocation W20222295191 @default.
• W2022229519 hasRelatedWork W1985706241 @default.
• W2022229519 hasRelatedWork W1987925654 @default.
• W2022229519 hasRelatedWork W2029953856 @default.
• W2022229519 hasRelatedWork W204684321 @default.
• W2022229519 hasRelatedWork W2062024095 @default.
• W2022229519 hasRelatedWork W2091312819 @default.
• W2022229519 hasRelatedWork W2118029289 @default.

• next