FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022230828> ?p ?o ?g. }

• W2022230828 endingPage "e16775" @default.
• W2022230828 startingPage "e16775" @default.
• W2022230828 abstract "Anxiety is a heterogeneous behavioral domain playing a role in a variety of neuropsychiatric diseases. While anxiety is the cardinal symptom in disorders such as panic disorder, co-morbid anxious behavior can occur in a variety of diseases. Stiff person syndrome (SPS) is a CNS disorder characterized by increased muscle tone and prominent agoraphobia and anxiety. Most patients have high-titer antibodies against glutamate decarboxylase (GAD) 65. The pathogenic role of these autoantibodies is unclear.We re-investigated a 53 year old woman with SPS and profound anxiety for GABA-A receptor binding in the amygdala with (11)C-flumazenil PET scan and studied the potential pathogenic role of purified IgG from her plasma filtrates containing high-titer antibodies against GAD 65. We passively transferred the IgG fraction intrathecally into rats and analyzed the effects using behavioral and in vivo electrophysiological methods. In cell culture, we measured the effect of patient IgG on GABA release from hippocampal neurons. Repetitive intrathecal application of purified patient IgG in rats resulted in an anxious phenotype resembling the core symptoms of the patient. Patient IgG selectively bound to rat amygdala, hippocampus, and frontal cortical areas. In cultured rat hippocampal neurons, patient IgG inhibited GABA release. In line with these experimental results, the GABA-A receptor binding potential was reduced in the patient's amygdala/hippocampus complex. No motor abnormalities were found in recipient rats.The observations in rats after passive transfer lead us to propose that anxiety-like behavior can be induced in rats by passive transfer of IgG from a SPS patient positive for anti-GAD 65 antibodies. Anxiety, in this case, thus may be an antibody-mediated phenomenon with consecutive disturbance of GABAergic signaling in the amygdala region." @default.
• W2022230828 created "2016-06-24" @default.
• W2022230828 creator A5002994159 @default.
• W2022230828 creator A5009208394 @default.
• W2022230828 creator A5027976216 @default.
• W2022230828 creator A5039754910 @default.
• W2022230828 creator A5043303840 @default.
• W2022230828 creator A5052673298 @default.
• W2022230828 creator A5053802958 @default.
• W2022230828 creator A5060737747 @default.
• W2022230828 creator A5063242451 @default.
• W2022230828 creator A5065722831 @default.
• W2022230828 creator A5071012492 @default.
• W2022230828 creator A5072393749 @default.
• W2022230828 creator A5089086027 @default.
• W2022230828 date "2011-02-08" @default.
• W2022230828 modified "2023-10-13" @default.
• W2022230828 title "Human Stiff-Person Syndrome IgG Induces Anxious Behavior in Rats" @default.
• W2022230828 cites W1508669381 @default.
• W2022230828 cites W1602497443 @default.
• W2022230828 cites W1968041541 @default.
• W2022230828 cites W1977833857 @default.
• W2022230828 cites W1986756933 @default.
• W2022230828 cites W1991654264 @default.
• W2022230828 cites W1997679949 @default.
• W2022230828 cites W1998735846 @default.
• W2022230828 cites W2006949329 @default.
• W2022230828 cites W2009047487 @default.
• W2022230828 cites W2019840124 @default.
• W2022230828 cites W2019967035 @default.
• W2022230828 cites W2023589715 @default.
• W2022230828 cites W2026049773 @default.
• W2022230828 cites W2027286990 @default.
• W2022230828 cites W2040725197 @default.
• W2022230828 cites W2044778826 @default.
• W2022230828 cites W2047570039 @default.
• W2022230828 cites W2077398525 @default.
• W2022230828 cites W2079900215 @default.
• W2022230828 cites W2083996609 @default.
• W2022230828 cites W2096866224 @default.
• W2022230828 cites W2100252544 @default.
• W2022230828 cites W2102291779 @default.
• W2022230828 cites W2113038139 @default.
• W2022230828 cites W2114634718 @default.
• W2022230828 cites W2118067546 @default.
• W2022230828 cites W2123159874 @default.
• W2022230828 cites W2126143811 @default.
• W2022230828 cites W2127387181 @default.
• W2022230828 cites W2140152000 @default.
• W2022230828 cites W2144573629 @default.
• W2022230828 cites W2151563375 @default.
• W2022230828 cites W2152647187 @default.
• W2022230828 cites W2159165179 @default.
• W2022230828 cites W2327060038 @default.
• W2022230828 cites W2341009442 @default.
• W2022230828 cites W2412222475 @default.
• W2022230828 cites W2747642795 @default.
• W2022230828 doi "https://doi.org/10.1371/journal.pone.0016775" @default.
• W2022230828 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3035624" @default.
• W2022230828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21346811" @default.
• W2022230828 hasPublicationYear "2011" @default.
• W2022230828 type Work @default.
• W2022230828 sameAs 2022230828 @default.
• W2022230828 citedByCount "48" @default.
• W2022230828 countsByYear W20222308282012 @default.
• W2022230828 countsByYear W20222308282013 @default.
• W2022230828 countsByYear W20222308282014 @default.
• W2022230828 countsByYear W20222308282015 @default.
• W2022230828 countsByYear W20222308282016 @default.
• W2022230828 countsByYear W20222308282017 @default.
• W2022230828 countsByYear W20222308282018 @default.
• W2022230828 countsByYear W20222308282019 @default.
• W2022230828 countsByYear W20222308282020 @default.
• W2022230828 countsByYear W20222308282022 @default.
• W2022230828 countsByYear W20222308282023 @default.
• W2022230828 crossrefType "journal-article" @default.
• W2022230828 hasAuthorship W2022230828A5002994159 @default.
• W2022230828 hasAuthorship W2022230828A5009208394 @default.
• W2022230828 hasAuthorship W2022230828A5027976216 @default.
• W2022230828 hasAuthorship W2022230828A5039754910 @default.
• W2022230828 hasAuthorship W2022230828A5043303840 @default.
• W2022230828 hasAuthorship W2022230828A5052673298 @default.
• W2022230828 hasAuthorship W2022230828A5053802958 @default.
• W2022230828 hasAuthorship W2022230828A5060737747 @default.
• W2022230828 hasAuthorship W2022230828A5063242451 @default.
• W2022230828 hasAuthorship W2022230828A5065722831 @default.
• W2022230828 hasAuthorship W2022230828A5071012492 @default.
• W2022230828 hasAuthorship W2022230828A5072393749 @default.
• W2022230828 hasAuthorship W2022230828A5089086027 @default.
• W2022230828 hasBestOaLocation W20222308281 @default.
• W2022230828 hasConcept C118552586 @default.
• W2022230828 hasConcept C126322002 @default.
• W2022230828 hasConcept C134018914 @default.
• W2022230828 hasConcept C148762608 @default.
• W2022230828 hasConcept C15744967 @default.
• W2022230828 hasConcept C169760540 @default.
• W2022230828 hasConcept C181199279 @default.
• W2022230828 hasConcept C203014093 @default.

• next