Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022231008> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W2022231008 abstract "The observation made several years ago that statins dramatically increase bone formation rates in rodents has provoked a much interest. Statins are natural product extracts that inhibit the enzyme, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the rate-limiting step in hepatic cholesterol biosynthesis. As a consequence, they reduce serum cholesterol and the subsequent risk of heart attack. These drugs are among the most widely prescribed in Western countries, with more than three million Americans taking a statin every day. Because there is no currently available and acceptable oral agent that stimulates formation of substantial amounts of new bone, this raises the possibility that safe oral agents such as these may be the longsought-after anabolic agent for the treatment of patients with established osteoporosis. Most of the statins exist as prodrugs (lactones), which do not inhibit HMG-CoA reductase but are readily converted by esterases to the active form. Although the first statins were natural product extracts, several of the more recent ones are synthetic, and appear to be more powerful and with different pharmacokinetic properties from the original statins. The statins were selected for their capacity to target the liver and most are subject to metabolism by cytochrome P450 enzymes in the liver. Some of these hepatic metabolites are active and some are inactive. Most of the statins are very lipid-soluble and enter cells easily, but some of the newer, synthetic statins, such as pravastatin and robuvastatin, are more water-soluble and probably depend on specific carrier mechanisms in hepatic cells for entry into these cells." @default.
- W2022231008 created "2016-06-24" @default.
- W2022231008 creator A5015533587 @default.
- W2022231008 date "2001-06-01" @default.
- W2022231008 modified "2023-10-16" @default.
- W2022231008 title "Statins and their potential for osteoporosis" @default.
- W2022231008 cites W1966064911 @default.
- W2022231008 cites W1988620153 @default.
- W2022231008 cites W1989528832 @default.
- W2022231008 cites W1994414479 @default.
- W2022231008 cites W2014018179 @default.
- W2022231008 cites W2020364703 @default.
- W2022231008 cites W2022350121 @default.
- W2022231008 cites W2031010510 @default.
- W2022231008 cites W2039999119 @default.
- W2022231008 cites W2041764060 @default.
- W2022231008 cites W2045369683 @default.
- W2022231008 cites W2052559711 @default.
- W2022231008 cites W2060736857 @default.
- W2022231008 cites W2063313335 @default.
- W2022231008 cites W2066781262 @default.
- W2022231008 cites W2070013537 @default.
- W2022231008 cites W2076261020 @default.
- W2022231008 cites W2089592874 @default.
- W2022231008 cites W2093164779 @default.
- W2022231008 cites W2096791952 @default.
- W2022231008 cites W2097576960 @default.
- W2022231008 cites W2108116605 @default.
- W2022231008 cites W2112728084 @default.
- W2022231008 cites W2123653119 @default.
- W2022231008 cites W2149507234 @default.
- W2022231008 cites W2161690532 @default.
- W2022231008 doi "https://doi.org/10.1138/2001029" @default.
- W2022231008 hasPublicationYear "2001" @default.
- W2022231008 type Work @default.
- W2022231008 sameAs 2022231008 @default.
- W2022231008 citedByCount "0" @default.
- W2022231008 crossrefType "journal-article" @default.
- W2022231008 hasAuthorship W2022231008A5015533587 @default.
- W2022231008 hasConcept C126322002 @default.
- W2022231008 hasConcept C2776541429 @default.
- W2022231008 hasConcept C71924100 @default.
- W2022231008 hasConceptScore W2022231008C126322002 @default.
- W2022231008 hasConceptScore W2022231008C2776541429 @default.
- W2022231008 hasConceptScore W2022231008C71924100 @default.
- W2022231008 hasLocation W20222310081 @default.
- W2022231008 hasOpenAccess W2022231008 @default.
- W2022231008 hasPrimaryLocation W20222310081 @default.
- W2022231008 hasRelatedWork W1995515455 @default.
- W2022231008 hasRelatedWork W2126903562 @default.
- W2022231008 hasRelatedWork W2354350842 @default.
- W2022231008 hasRelatedWork W2358157500 @default.
- W2022231008 hasRelatedWork W2387223170 @default.
- W2022231008 hasRelatedWork W2748952813 @default.
- W2022231008 hasRelatedWork W2899084033 @default.
- W2022231008 hasRelatedWork W2905181029 @default.
- W2022231008 hasRelatedWork W3032375762 @default.
- W2022231008 hasRelatedWork W4248933460 @default.
- W2022231008 isParatext "false" @default.
- W2022231008 isRetracted "false" @default.
- W2022231008 magId "2022231008" @default.
- W2022231008 workType "article" @default.