Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022231009> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2022231009 abstract "Breast cancer with the triple-negative phenotype (TNBC) are ER-negative, PR-negative and ERBB2 (HER2)-negative and represent one of the most aggressive and difficult to treat subtypes of human breast cancer. TNBC is highly over-represented in African American breast cancer patients and determining the genetic and molecular basis for this incidence and the biological basis for the aggressiveness of TNBCs are largely unknown and of high priority. The transcription factor SLUG, which controls epithelial to mesenchymal transition, stem cell phenotypes and therapeutic responsiveness, is highly expressed in the basal-type TNBC cells, making it a candidate master regulator of the TNBC phenotype. Plakoglobin, also known as γ-catenin or JUP, is a member of the armadillo motifcontaining proteins. This protein is a critical component of the desmosomal structure conferring structural integrity and resistance from mechanical stress to epithelial cells in tissues. We report here that SLUG inhibits the expression of several desmosomal proteins including the plakoglobin gene directly and thus, among other downstream effects, help disseminating the TNBC cells. Overexpression of SLUG in the SLUG-deficient cancer cells significantly decreased the levels of mRNA and protein of plakoglobin. On the contrary, knockdown of SLUG in SLUG-high TNBC cells elevated the levels of plakoglobin. Inhibition of SLUG activity with a molecular decoy in the TNBC cells abrogated the inhibitory effect of SLUG on plakoglobin gene expression. Although overexpression of SLUG in the SLUG-deficient cells elevated the invasiveness and motility of these cells, knockdown of plakoglobin only affected the growth and migration rates of these cells. This study thus implicates high levels of SLUG and low levels of plakoglobin as determinants in the progression of highly disseminating breast cancer of the TNBC type. Supported by the DOD-CDMRP BCRP Grants W81XWH-06-1-0466, W81XWH-08-1-0446, BC086542, and the Susan G. Komen Breast Cancer Foundation grant# BCTR0707627 to GC. Citation Information: Cancer Epidemiol Biomarkers Prev 2011;20(10 Suppl):B35." @default.
- W2022231009 created "2016-06-24" @default.
- W2022231009 creator A5024777354 @default.
- W2022231009 creator A5076169837 @default.
- W2022231009 creator A5083895051 @default.
- W2022231009 creator A5090558749 @default.
- W2022231009 date "2011-09-01" @default.
- W2022231009 modified "2023-09-27" @default.
- W2022231009 title "Abstract B35: SLUG-induced plakoglobin gene repression in triplenegative breast cancer cells" @default.
- W2022231009 doi "https://doi.org/10.1158/1055-9965.disp-11-b35" @default.
- W2022231009 hasPublicationYear "2011" @default.
- W2022231009 type Work @default.
- W2022231009 sameAs 2022231009 @default.
- W2022231009 citedByCount "0" @default.
- W2022231009 crossrefType "proceedings-article" @default.
- W2022231009 hasAuthorship W2022231009A5024777354 @default.
- W2022231009 hasAuthorship W2022231009A5076169837 @default.
- W2022231009 hasAuthorship W2022231009A5083895051 @default.
- W2022231009 hasAuthorship W2022231009A5090558749 @default.
- W2022231009 hasConcept C104317684 @default.
- W2022231009 hasConcept C121608353 @default.
- W2022231009 hasConcept C137620995 @default.
- W2022231009 hasConcept C173396325 @default.
- W2022231009 hasConcept C2779013556 @default.
- W2022231009 hasConcept C2781381752 @default.
- W2022231009 hasConcept C30145163 @default.
- W2022231009 hasConcept C48220470 @default.
- W2022231009 hasConcept C502942594 @default.
- W2022231009 hasConcept C54355233 @default.
- W2022231009 hasConcept C62478195 @default.
- W2022231009 hasConcept C76419328 @default.
- W2022231009 hasConcept C86803240 @default.
- W2022231009 hasConcept C95444343 @default.
- W2022231009 hasConcept C96232424 @default.
- W2022231009 hasConceptScore W2022231009C104317684 @default.
- W2022231009 hasConceptScore W2022231009C121608353 @default.
- W2022231009 hasConceptScore W2022231009C137620995 @default.
- W2022231009 hasConceptScore W2022231009C173396325 @default.
- W2022231009 hasConceptScore W2022231009C2779013556 @default.
- W2022231009 hasConceptScore W2022231009C2781381752 @default.
- W2022231009 hasConceptScore W2022231009C30145163 @default.
- W2022231009 hasConceptScore W2022231009C48220470 @default.
- W2022231009 hasConceptScore W2022231009C502942594 @default.
- W2022231009 hasConceptScore W2022231009C54355233 @default.
- W2022231009 hasConceptScore W2022231009C62478195 @default.
- W2022231009 hasConceptScore W2022231009C76419328 @default.
- W2022231009 hasConceptScore W2022231009C86803240 @default.
- W2022231009 hasConceptScore W2022231009C95444343 @default.
- W2022231009 hasConceptScore W2022231009C96232424 @default.
- W2022231009 hasLocation W20222310091 @default.
- W2022231009 hasOpenAccess W2022231009 @default.
- W2022231009 hasPrimaryLocation W20222310091 @default.
- W2022231009 hasRelatedWork W2089189902 @default.
- W2022231009 hasRelatedWork W2098100072 @default.
- W2022231009 hasRelatedWork W2131355268 @default.
- W2022231009 hasRelatedWork W2276043341 @default.
- W2022231009 hasRelatedWork W2531239195 @default.
- W2022231009 hasRelatedWork W2567848196 @default.
- W2022231009 hasRelatedWork W2571160404 @default.
- W2022231009 hasRelatedWork W2602318789 @default.
- W2022231009 hasRelatedWork W2626892568 @default.
- W2022231009 hasRelatedWork W2741210235 @default.
- W2022231009 hasRelatedWork W2804154867 @default.
- W2022231009 hasRelatedWork W2882990360 @default.
- W2022231009 hasRelatedWork W2910817347 @default.
- W2022231009 hasRelatedWork W2912549221 @default.
- W2022231009 hasRelatedWork W2967227554 @default.
- W2022231009 hasRelatedWork W2992216278 @default.
- W2022231009 hasRelatedWork W3040142451 @default.
- W2022231009 hasRelatedWork W3123798534 @default.
- W2022231009 hasRelatedWork W3175946598 @default.
- W2022231009 hasRelatedWork W3195665241 @default.
- W2022231009 isParatext "false" @default.
- W2022231009 isRetracted "false" @default.
- W2022231009 magId "2022231009" @default.
- W2022231009 workType "article" @default.