FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022231372> ?p ?o ?g. }

• W2022231372 endingPage "2235" @default.
• W2022231372 startingPage "2229" @default.
• W2022231372 abstract "Two DNA elements which we have termed SAA and GAG have been shown to control expression of the rat amyloid precursor protein (APP) gene, and the region containing the SAA element has been shown to interact with nuclear proteins [Hoffman and Chemak (1994) Blochem. Blophys. Res. Commun. 201, 610–617]. In this report we study DNA sequences and proteins which influence the activity of the SAA element. An oligonucleotide containing the SAA element is specifically bound by nuclear proteins derived from rat PC12 cells, consistently forming four complexes designated C25, C30, C35 and C40 in electrophoretlc mobility shift assays (EMSAs). We demonstrate that the C25, C30 and C40 complexes involve the binding of nuclear proteins to an SP1 consensus sequence located within the SAA element and that the C25 complex contains a protein anti-genically related to the human SP1 protein. We establish further that the C35 complex requires a USF recognition site located within the SAA element and contains a protein antigenically related to the human upstream stimulatory factor (USF) protein. Using APP promoter/luciferase reporter gene constructs, we demonstrate that both the SP1 and the USF sites can play a role in the transcriptional activity of the SAA element. Finally, we show that complexes similar to the C25, C30 and C35 complexes are formed by rat cortex nuclear extracts and the SAA element in EMSA experiments, suggesting the relevance of our in vitro observations to the in vivo functioning of the rat APP promoter." @default.
• W2022231372 created "2016-06-24" @default.
• W2022231372 creator A5033229348 @default.
• W2022231372 creator A5036752992 @default.
• W2022231372 date "1995-01-01" @default.
• W2022231372 modified "2023-10-16" @default.
• W2022231372 title "DNA binding and regulatory effects of transcription factors SP1 and USF at the rat amyloid precursor protein gene promoter" @default.
• W2022231372 cites W1495417445 @default.
• W2022231372 cites W1965258786 @default.
• W2022231372 cites W1982929714 @default.
• W2022231372 cites W1985792375 @default.
• W2022231372 cites W1992176243 @default.
• W2022231372 cites W1993243592 @default.
• W2022231372 cites W2011802630 @default.
• W2022231372 cites W2012813919 @default.
• W2022231372 cites W2025723633 @default.
• W2022231372 cites W2038718099 @default.
• W2022231372 cites W2040193953 @default.
• W2022231372 cites W2059269241 @default.
• W2022231372 cites W2061308198 @default.
• W2022231372 cites W2068225545 @default.
• W2022231372 cites W2084972185 @default.
• W2022231372 cites W2093458878 @default.
• W2022231372 cites W2151951496 @default.
• W2022231372 cites W2405724104 @default.
• W2022231372 cites W2888511473 @default.
• W2022231372 cites W4323238289 @default.
• W2022231372 doi "https://doi.org/10.1093/nar/23.12.2229" @default.
• W2022231372 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/307012" @default.
• W2022231372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7610052" @default.
• W2022231372 hasPublicationYear "1995" @default.
• W2022231372 type Work @default.
• W2022231372 sameAs 2022231372 @default.
• W2022231372 citedByCount "55" @default.
• W2022231372 countsByYear W20222313722012 @default.
• W2022231372 countsByYear W20222313722013 @default.
• W2022231372 countsByYear W20222313722014 @default.
• W2022231372 countsByYear W20222313722015 @default.
• W2022231372 countsByYear W20222313722016 @default.
• W2022231372 countsByYear W20222313722017 @default.
• W2022231372 countsByYear W20222313722018 @default.
• W2022231372 countsByYear W20222313722020 @default.
• W2022231372 crossrefType "journal-article" @default.
• W2022231372 hasAuthorship W2022231372A5033229348 @default.
• W2022231372 hasAuthorship W2022231372A5036752992 @default.
• W2022231372 hasBestOaLocation W20222313722 @default.
• W2022231372 hasConcept C101762097 @default.
• W2022231372 hasConcept C104317684 @default.
• W2022231372 hasConcept C132376346 @default.
• W2022231372 hasConcept C138885662 @default.
• W2022231372 hasConcept C142724271 @default.
• W2022231372 hasConcept C150194340 @default.
• W2022231372 hasConcept C153911025 @default.
• W2022231372 hasConcept C161733203 @default.
• W2022231372 hasConcept C179926584 @default.
• W2022231372 hasConcept C183978625 @default.
• W2022231372 hasConcept C21592294 @default.
• W2022231372 hasConcept C2779134260 @default.
• W2022231372 hasConcept C29512474 @default.
• W2022231372 hasConcept C31705614 @default.
• W2022231372 hasConcept C41895202 @default.
• W2022231372 hasConcept C502032728 @default.
• W2022231372 hasConcept C552990157 @default.
• W2022231372 hasConcept C55493867 @default.
• W2022231372 hasConcept C71924100 @default.
• W2022231372 hasConcept C86339819 @default.
• W2022231372 hasConcept C86803240 @default.
• W2022231372 hasConcept C94966510 @default.
• W2022231372 hasConceptScore W2022231372C101762097 @default.
• W2022231372 hasConceptScore W2022231372C104317684 @default.
• W2022231372 hasConceptScore W2022231372C132376346 @default.
• W2022231372 hasConceptScore W2022231372C138885662 @default.
• W2022231372 hasConceptScore W2022231372C142724271 @default.
• W2022231372 hasConceptScore W2022231372C150194340 @default.
• W2022231372 hasConceptScore W2022231372C153911025 @default.
• W2022231372 hasConceptScore W2022231372C161733203 @default.
• W2022231372 hasConceptScore W2022231372C179926584 @default.
• W2022231372 hasConceptScore W2022231372C183978625 @default.
• W2022231372 hasConceptScore W2022231372C21592294 @default.
• W2022231372 hasConceptScore W2022231372C2779134260 @default.
• W2022231372 hasConceptScore W2022231372C29512474 @default.
• W2022231372 hasConceptScore W2022231372C31705614 @default.
• W2022231372 hasConceptScore W2022231372C41895202 @default.
• W2022231372 hasConceptScore W2022231372C502032728 @default.
• W2022231372 hasConceptScore W2022231372C552990157 @default.
• W2022231372 hasConceptScore W2022231372C55493867 @default.
• W2022231372 hasConceptScore W2022231372C71924100 @default.
• W2022231372 hasConceptScore W2022231372C86339819 @default.
• W2022231372 hasConceptScore W2022231372C86803240 @default.
• W2022231372 hasConceptScore W2022231372C94966510 @default.
• W2022231372 hasIssue "12" @default.
• W2022231372 hasLocation W20222313721 @default.
• W2022231372 hasLocation W20222313722 @default.
• W2022231372 hasLocation W20222313723 @default.
• W2022231372 hasLocation W20222313724 @default.
• W2022231372 hasOpenAccess W2022231372 @default.
• W2022231372 hasPrimaryLocation W20222313721 @default.
• W2022231372 hasRelatedWork W1616867617 @default.

• next