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• W2022232635 abstract "To determine the protective effects of remote post-conditioning on ischemic brain lesions caused by middle cerebral artery (MCA) occlusion in rats.A total of 54 animals were used in this present study. An ischemic stroke model was generated by 90-minute occlusion of right MCA (n = 42). Twelve rats were used as control for studying edema and blood-brain barrier (BBB) integrity. Remote post-conditioning was conducted immediately after MCA occlusion in the bilateral lower limb by occluding and releasing the femoral artery for three cycles; each occlusion and release lasted for 10 minutes. After 24 hours of reperfusion, the cerebral infarct volumes were quantified by 2,3,4-triphenytetrazolium-chloride, brain water content was determined by dry/wet weight method, and damage to the BBB was determined by Evans blue extravasation.Remote post-conditioning significantly reduced brain infarct damage (P<0.0001). Brain edema was significantly (P<0.01) reduced after stroke in the remote post-conditioning group. BBB leakage was significantly reduced in the remote post-conditioning group when compared to the control ischemic groups (P<0.05).These results provide evidence that remote post-conditioning, which was initiated after ischemia and before reperfusion, protects against brain injury in experimental ischemic stroke." @default.
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• W2022232635 date "2011-06-01" @default.
• W2022232635 modified "2023-09-30" @default.
• W2022232635 title "Remote ischemic post-conditioning reduced brain damage in experimental ischemia/reperfusion injury" @default.
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• W2022232635 doi "https://doi.org/10.1179/016164111x13007856084241" @default.
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