Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022232638> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2022232638 endingPage "133" @default.
- W2022232638 startingPage "126" @default.
- W2022232638 abstract "Levosimendan is a novel calcium sensitizer that is an established treatment for congestive heart failure. In coronary vessels, levosimendan has a vasorelaxant, endothelium-independent effect and an antagonistic effect on endothelin-1 (ET-1). There is also some data for a neuroprotective effect in a traumatic brain injury model, and levosimendan can prevent the reduction of the luminal area of the basilar artery. We considered that patients who suffer heart attack after subarachnoid hemorrhage (SAH) might respond well to levosimendan, which might also be useful to induce hypertension in patients with cerebral vasospasm.However, the functional effects of levosimendan in the cerebrovasculature are unknown. Here, we investigated the functional role of levosimendan on rat basilar artery by assessing vasocontractile reactivity in response to ET-1, sarafotoxin S6c, acetylcholine, sodium nitroprusside, cGMP, and prostaglandin F2α (PGF).Contrary to observations in coronary vessels, levosimendan did not affect the ET-1 system in cerebral arteries; neither ET(A)-receptor-induced contraction nor ET(B)-receptor-dependent relaxation were changed. For the nitric oxide (NO) pathway, only a slight increase was detected. Rather, levosimendan caused significant and dose-dependent relaxation after PGF precontraction.To our knowledge, this is the first report that describes levosimendan-induced functional changes of cerebrovascular contractility and relaxation. Under physiological conditions, levosimendan did not influence ET(A)/ET(B)-receptor signaling or the NO pathway. Interestingly, levosimendan seemed to affect the prostaglandin system and dosedependently reversed PGF- induced contraction. We did not detect a vasospastic potential for levosimedan in cerebral arteries, suggesting that it would be safe for use in SAH patients." @default.
- W2022232638 created "2016-06-24" @default.
- W2022232638 creator A5023557457 @default.
- W2022232638 creator A5024876270 @default.
- W2022232638 creator A5037459752 @default.
- W2022232638 creator A5044703028 @default.
- W2022232638 creator A5075817512 @default.
- W2022232638 creator A5078616535 @default.
- W2022232638 creator A5083545843 @default.
- W2022232638 creator A5091472808 @default.
- W2022232638 date "2013-04-01" @default.
- W2022232638 modified "2023-10-01" @default.
- W2022232638 title "Functional Effects of Levosimendan in Rat Basilar Arteries In Vitro" @default.
- W2022232638 doi "https://doi.org/10.2174/1567202611310020005" @default.
- W2022232638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23469954" @default.
- W2022232638 hasPublicationYear "2013" @default.
- W2022232638 type Work @default.
- W2022232638 sameAs 2022232638 @default.
- W2022232638 citedByCount "9" @default.
- W2022232638 countsByYear W20222326382014 @default.
- W2022232638 countsByYear W20222326382015 @default.
- W2022232638 countsByYear W20222326382016 @default.
- W2022232638 countsByYear W20222326382017 @default.
- W2022232638 crossrefType "journal-article" @default.
- W2022232638 hasAuthorship W2022232638A5023557457 @default.
- W2022232638 hasAuthorship W2022232638A5024876270 @default.
- W2022232638 hasAuthorship W2022232638A5037459752 @default.
- W2022232638 hasAuthorship W2022232638A5044703028 @default.
- W2022232638 hasAuthorship W2022232638A5075817512 @default.
- W2022232638 hasAuthorship W2022232638A5078616535 @default.
- W2022232638 hasAuthorship W2022232638A5083545843 @default.
- W2022232638 hasAuthorship W2022232638A5091472808 @default.
- W2022232638 hasConcept C120770815 @default.
- W2022232638 hasConcept C126322002 @default.
- W2022232638 hasConcept C164705383 @default.
- W2022232638 hasConcept C171614378 @default.
- W2022232638 hasConcept C2776820941 @default.
- W2022232638 hasConcept C2777335384 @default.
- W2022232638 hasConcept C2777736543 @default.
- W2022232638 hasConcept C2778198053 @default.
- W2022232638 hasConcept C2778506911 @default.
- W2022232638 hasConcept C2779610285 @default.
- W2022232638 hasConcept C2781012200 @default.
- W2022232638 hasConcept C42219234 @default.
- W2022232638 hasConcept C519581460 @default.
- W2022232638 hasConcept C71924100 @default.
- W2022232638 hasConceptScore W2022232638C120770815 @default.
- W2022232638 hasConceptScore W2022232638C126322002 @default.
- W2022232638 hasConceptScore W2022232638C164705383 @default.
- W2022232638 hasConceptScore W2022232638C171614378 @default.
- W2022232638 hasConceptScore W2022232638C2776820941 @default.
- W2022232638 hasConceptScore W2022232638C2777335384 @default.
- W2022232638 hasConceptScore W2022232638C2777736543 @default.
- W2022232638 hasConceptScore W2022232638C2778198053 @default.
- W2022232638 hasConceptScore W2022232638C2778506911 @default.
- W2022232638 hasConceptScore W2022232638C2779610285 @default.
- W2022232638 hasConceptScore W2022232638C2781012200 @default.
- W2022232638 hasConceptScore W2022232638C42219234 @default.
- W2022232638 hasConceptScore W2022232638C519581460 @default.
- W2022232638 hasConceptScore W2022232638C71924100 @default.
- W2022232638 hasIssue "2" @default.
- W2022232638 hasLocation W20222326381 @default.
- W2022232638 hasLocation W20222326382 @default.
- W2022232638 hasOpenAccess W2022232638 @default.
- W2022232638 hasPrimaryLocation W20222326381 @default.
- W2022232638 hasRelatedWork W1605889535 @default.
- W2022232638 hasRelatedWork W1973763934 @default.
- W2022232638 hasRelatedWork W1977959066 @default.
- W2022232638 hasRelatedWork W2056710153 @default.
- W2022232638 hasRelatedWork W2133118607 @default.
- W2022232638 hasRelatedWork W2147342711 @default.
- W2022232638 hasRelatedWork W2349146037 @default.
- W2022232638 hasRelatedWork W2361770655 @default.
- W2022232638 hasRelatedWork W2369315206 @default.
- W2022232638 hasRelatedWork W3151036313 @default.
- W2022232638 hasVolume "10" @default.
- W2022232638 isParatext "false" @default.
- W2022232638 isRetracted "false" @default.
- W2022232638 magId "2022232638" @default.
- W2022232638 workType "article" @default.