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• W2022233058 abstract "This report introduces a gonadotrope-specific cre transgenic mouse capable of ablating floxed genes in mature pituitary gonadotropes. Initial analysis of this transgenic line, Tg(Lhb-cre)1Sac, reveals that expression is limited to the pituitary cells that produce luteinizing hormone beta, beginning appropriately at e17.5. Cre activity is detectable by a reporter gene in nearly every LHbeta-producing cell, but the remaining hormone-producing cell types and other organs exhibit little to no activity. We used the Tg(Lhb-cre)1Sac strain to assess the role Pitx2 in gonadotrope function. The gonadotrope-specific Pitx2 knockout mice exhibit normal expression of LHbeta, sexual maturation, and fertility, suggesting that Pitx2 is not required for gonadotrope maintenance or for regulated production of gonadotropins." @default.
• W2022233058 created "2016-06-24" @default.
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• W2022233058 date "2008-10-01" @default.
• W2022233058 modified "2023-10-07" @default.
• W2022233058 title "<i>Pitx2</i>deletion in pituitary gonadotropes is compatible with gonadal development, puberty, and fertility" @default.
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• W2022233058 doi "https://doi.org/10.1002/dvg.20398" @default.
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