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- W2022233586 abstract "Tetraplatin inhibited choline acetyltransferase (CAT) from rat and bovine brain with I50 values of 13.5 and 40 microM, respectively. At 0.5 mM concentration, tetraplatin exhibited inhibition of the rat brain enzyme by 89%, whereas cisplatin yielded only 18% inhibition. With bovine CAT, tetraplatin showed noncompetitive inhibition with the substrate choline, Km 337 microM, Ki 29 microM, Vmax 2.83 nmoles acetylcholine formed/min/mg protein, and competitive inhibition with the substrate acetyl-CoA, Km 21 microM, Ki 16 microM, Vmax 3.85 nmoles acetylcholine formed/min/mg protein." @default.
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- W2022233586 date "1987-08-01" @default.
- W2022233586 modified "2023-09-27" @default.
- W2022233586 title "Inhibition of brain choline acetyltransferase by tetraplatin" @default.
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- W2022233586 doi "https://doi.org/10.1016/0361-9230(87)90094-3" @default.
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