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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022234757> ?p ?o ?g. }

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• W2022234757 abstract "To assess the safety and efficacy of a monoclonal antibody (MAb) to intercellular adhesion molecule 1 (ICAM-1; CD54) in rheumatoid arthritis (RA).A phase I/II, open-label, dose-escalation study of 32 patients.During treatment, a peripheral CD3+/CD4+ lymphocytosis was noted, and several patients demonstrated transient cutaneous anergy, which suggests that therapy modified T cell recirculation. Thirteen of the 23 patients who received 5 days of treatment demonstrated clinical improvement through day 29, and 9 of 23 through day 60. Adverse effects were minor and transient.Anti-ICAM-1 MAb therapy was well tolerated, resulted in a transient alteration in T lymphocyte recirculation, and effected clinical improvement in some RA patients." @default.
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• W2022234757 date "1994-07-01" @default.
• W2022234757 modified "2023-10-17" @default.
• W2022234757 title "Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1" @default.
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• W2022234757 doi "https://doi.org/10.1002/art.1780370703" @default.
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