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• W2022234828 endingPage "948" @default.
• W2022234828 startingPage "943" @default.
• W2022234828 abstract "Pituitary adenylate cyclase-activating polypeptide (PACAP) is localized in pancreatic nerve fibers and islets and potently augments glucose-induced insulin secretion. The present study explored a possible extra-pancreatic action of PACAP. The specific PACAP receptor (PAC1 receptor) was expressed in the rat fat tissue and 3T3-LI adipocytes. PACAP-38 (10 nM) significantly enhanced insulin-induced 2-deoxyglucose uptake by 3T3-L1 adipocytes. Insulin-stimulated phosphatidylinositol 3-kinase activity was further increased by PACAP-38, whereas the tyrosine-phosphorylation of insulin receptor beta-subunit and insulin receptor substrate-1 was unaltered by PACAP-38. These results reveal that PACAP-38 enhances insulin-induced glucose uptake, an effect probably mediated by insulin-stimulated phosphatidyl-inositol 3-kinase, and that PACAP potentiates not only insulin secretion, but also insulin action in adipocytes." @default.
• W2022234828 created "2016-06-24" @default.
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• W2022234828 date "1999-01-01" @default.
• W2022234828 modified "2023-09-27" @default.
• W2022234828 title "Insulinotropin PACAP potentiates insulin-stimulated glucose uptake in 3T3 L1 cells☆" @default.
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• W2022234828 doi "https://doi.org/10.1016/s0196-9781(99)00085-6" @default.
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