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- W2022236194 abstract "In today's Lancet, David Jacobsohn and colleagues summarise their experience with reduced-intensity conditioning or non-myeloablative stem-cell transplantation for the treatment of various non-malignant diseases in children, including sickle-cell anaemia, X-linked hyper-IgM syndrome, Sandhoff's disease, and immune dysfunction syndromes. The use of non-myeloablative stem-cell transplantation, with fludarabine and busulfan and later busulfex, for more reliable bioavailability, especially in children and to reduce possible liver toxicity from first pass of the absorbed compound, was pioneered in Jerusalem in adults and subsequently in children. 1 Slavin S Nagler A Naparstek E et al. Non–myeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and non malignant hematologic diseases. Blood. 1998; 91: 756-763 PubMed Google Scholar Reduced intensity haemopoietic stem-cell transplantation for treatment of non-malignant diseases in childrenThis reduced intensity regimen followed by HSCT provides a good alternative to myeloablative HSCT for children with non-malignant disorders, except for haemoglobinopathies, in which engraftment is poor. Even patients with unrelated donor haemopoietic stem-cell transplants had adequate engraftment with acceptable toxicities. Full-Text PDF" @default.
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- W2022236194 date "2004-07-01" @default.
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- W2022236194 title "Smarter rather than stronger treatment of haematological malignancies and non-malignant indications for stem-cell transplantation" @default.
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- W2022236194 doi "https://doi.org/10.1016/s0140-6736(04)16652-x" @default.
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