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- W2022237409 abstract "Mu-opioid receptors (MOR) are the therapeutic target for opiate analgesic drugs and also mediate many of the side-effects and addiction liability of these compounds. MOR is a seven-transmembrane domain receptor that couples to intracellular signaling molecules by activating heterotrimeric G proteins. However, the receptor and G protein do not function in isolation but their activities are moderated by several accessory and scaffolding proteins. One important group of accessory proteins is the regulator of G protein signaling (RGS) protein family, a large family of more than thirty members which bind to the activated Gα subunit of the heterotrimeric G protein and serve to accelerate signal termination. This action negatively modulates receptor signaling and subsequent behavior. Several members of this family, in particular RGS4 and RGS9-2 have been demonstrated to influence MOR signaling and morphine-induced behaviors, including reward. Moreover, this interaction is not unidirectional since morphine has been demonstrated to modulate expression levels of RGS proteins, especially RGS4 and RGS9-2, in a tissue and time dependent manner. In this article, I will discuss our work on the regulation of MOR signaling by RGS protein activity in cultured cell systems in the context of other in vitro and behavioral studies. In addition I will consider implications of the bi-directional interaction between MOR receptor activation and RGS protein activity and whether RGS proteins might provide a suitable and novel target for medications to manage addictive behaviors." @default.
- W2022237409 created "2016-06-24" @default.
- W2022237409 creator A5022375777 @default.
- W2022237409 date "2012-03-01" @default.
- W2022237409 modified "2023-10-14" @default.
- W2022237409 title "μ-Opioid receptors and regulators of G protein signaling (RGS) proteins: From a symposium on new concepts in mu-opioid pharmacology" @default.
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- W2022237409 doi "https://doi.org/10.1016/j.drugalcdep.2011.10.027" @default.
- W2022237409 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3288798" @default.
- W2022237409 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22129844" @default.
- W2022237409 hasPublicationYear "2012" @default.
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