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- W2022237652 abstract "The naturally occurring cytotoxic saponin 28-O-beta-d-glucopyranosylbetulinic acid 3beta-O-alpha-l-arabinopyranoside (3) was easily synthesized along with seven bidesmosidic saponins starting from the lupane-type triterpenoids betulin (1) and betulinic acid (2). As highlighted by the preliminary cytotoxicity evaluation against A549, DLD-1, MCF7, and PC-3 human cancer cell lines, the bidesmosidic betulin saponin 22a, bearing alpha-l-rhamnopyranoside moieties at both C-3 and C-28 positions, was determined to be a potent cytotoxic agent (IC(50) 1.8-1.9 microM)." @default.
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- W2022237652 date "2008-12-30" @default.
- W2022237652 modified "2023-10-14" @default.
- W2022237652 title "Synthesis and Cytotoxicity of Bidesmosidic Betulin and Betulinic Acid Saponins" @default.
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- W2022237652 doi "https://doi.org/10.1021/np800579x" @default.
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