FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022237684> ?p ?o ?g. }

• W2022237684 endingPage "228" @default.
• W2022237684 startingPage "217" @default.
• W2022237684 abstract "Glutamine synthetase (GS) catalyzes the ligation of glutamate and ammonia to form glutamine, with concomitant hydrolysis of ATP. In mammals, the activity eliminates cytotoxic ammonia, at the same time converting neurotoxic glutamate to harmless glutamine; there are a number of links between changes in GS activity and neurodegenerative disorders, such as Alzheimer's disease. In plants, because of its importance in the assimilation and re-assimilation of ammonia, the enzyme is a target of some herbicides. GS is also a central component of bacterial nitrogen metabolism and a potential drug target. Previous studies had investigated the structures of bacterial and plant GSs. In the present publication, we report the first structures of mammalian GSs. The apo form of the canine enzyme was solved by molecular replacement and refined at a resolution of 3 A. Two structures of human glutamine synthetase represent complexes with: a) phosphate, ADP, and manganese, and b) a phosphorylated form of the inhibitor methionine sulfoximine, ADP and manganese; these structures were refined to resolutions of 2.05 A and 2.6 A, respectively. Loop movements near the active site generate more closed forms of the eukaryotic enzymes when substrates are bound; the largest changes are associated with the binding of the nucleotide. Comparisons with earlier structures provide a basis for the design of drugs that are specifically directed at either human or bacterial enzymes. The site of binding the amino acid substrate is highly conserved in bacterial and eukaryotic GSs, whereas the nucleotide binding site varies to a much larger degree. Thus, the latter site offers the best target for specific drug design. Differences between mammalian and plant enzymes are much more subtle, suggesting that herbicides targeting GS must be designed with caution." @default.
• W2022237684 created "2016-06-24" @default.
• W2022237684 creator A5018683664 @default.
• W2022237684 creator A5028665730 @default.
• W2022237684 creator A5044522250 @default.
• W2022237684 creator A5051132348 @default.
• W2022237684 creator A5066622264 @default.
• W2022237684 creator A5079845863 @default.
• W2022237684 date "2008-01-01" @default.
• W2022237684 modified "2023-10-18" @default.
• W2022237684 title "Crystal Structures of Mammalian Glutamine Synthetases Illustrate Substrate-Induced Conformational Changes and Provide Opportunities for Drug and Herbicide Design" @default.
• W2022237684 cites W1563191931 @default.
• W2022237684 cites W1744821831 @default.
• W2022237684 cites W179648318 @default.
• W2022237684 cites W1964525381 @default.
• W2022237684 cites W1968287909 @default.
• W2022237684 cites W1976166144 @default.
• W2022237684 cites W1976422615 @default.
• W2022237684 cites W1986085513 @default.
• W2022237684 cites W1986830449 @default.
• W2022237684 cites W1993404146 @default.
• W2022237684 cites W1994342014 @default.
• W2022237684 cites W1995017064 @default.
• W2022237684 cites W2000118992 @default.
• W2022237684 cites W2001641653 @default.
• W2022237684 cites W2012144638 @default.
• W2022237684 cites W2013083986 @default.
• W2022237684 cites W2014694459 @default.
• W2022237684 cites W2022039597 @default.
• W2022237684 cites W2024950378 @default.
• W2022237684 cites W2032931308 @default.
• W2022237684 cites W2033098008 @default.
• W2022237684 cites W2035778257 @default.
• W2022237684 cites W2038840577 @default.
• W2022237684 cites W2047132220 @default.
• W2022237684 cites W2062281403 @default.
• W2022237684 cites W2071157004 @default.
• W2022237684 cites W2077976356 @default.
• W2022237684 cites W2078893885 @default.
• W2022237684 cites W2086963340 @default.
• W2022237684 cites W2088987512 @default.
• W2022237684 cites W2097493124 @default.
• W2022237684 cites W2112200653 @default.
• W2022237684 cites W2114867389 @default.
• W2022237684 cites W2116275717 @default.
• W2022237684 cites W2117124707 @default.
• W2022237684 cites W2122865644 @default.
• W2022237684 cites W2128482141 @default.
• W2022237684 cites W2136126428 @default.
• W2022237684 cites W2144081223 @default.
• W2022237684 cites W2144192914 @default.
• W2022237684 cites W2146479955 @default.
• W2022237684 cites W2146881071 @default.
• W2022237684 cites W2162244749 @default.
• W2022237684 cites W4242482565 @default.
• W2022237684 cites W4251672032 @default.
• W2022237684 doi "https://doi.org/10.1016/j.jmb.2007.10.029" @default.
• W2022237684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18005987" @default.
• W2022237684 hasPublicationYear "2008" @default.
• W2022237684 type Work @default.
• W2022237684 sameAs 2022237684 @default.
• W2022237684 citedByCount "124" @default.
• W2022237684 countsByYear W20222376842012 @default.
• W2022237684 countsByYear W20222376842013 @default.
• W2022237684 countsByYear W20222376842014 @default.
• W2022237684 countsByYear W20222376842015 @default.
• W2022237684 countsByYear W20222376842016 @default.
• W2022237684 countsByYear W20222376842017 @default.
• W2022237684 countsByYear W20222376842018 @default.
• W2022237684 countsByYear W20222376842019 @default.
• W2022237684 countsByYear W20222376842020 @default.
• W2022237684 countsByYear W20222376842021 @default.
• W2022237684 countsByYear W20222376842022 @default.
• W2022237684 countsByYear W20222376842023 @default.
• W2022237684 crossrefType "journal-article" @default.
• W2022237684 hasAuthorship W2022237684A5018683664 @default.
• W2022237684 hasAuthorship W2022237684A5028665730 @default.
• W2022237684 hasAuthorship W2022237684A5044522250 @default.
• W2022237684 hasAuthorship W2022237684A5051132348 @default.
• W2022237684 hasAuthorship W2022237684A5066622264 @default.
• W2022237684 hasAuthorship W2022237684A5079845863 @default.
• W2022237684 hasBestOaLocation W20222376842 @default.
• W2022237684 hasConcept C104317684 @default.
• W2022237684 hasConcept C107824862 @default.
• W2022237684 hasConcept C181199279 @default.
• W2022237684 hasConcept C185592680 @default.
• W2022237684 hasConcept C2776376580 @default.
• W2022237684 hasConcept C2779289688 @default.
• W2022237684 hasConcept C2779349466 @default.
• W2022237684 hasConcept C41183919 @default.
• W2022237684 hasConcept C512185932 @default.
• W2022237684 hasConcept C515207424 @default.
• W2022237684 hasConcept C55493867 @default.
• W2022237684 hasConcept C71240020 @default.
• W2022237684 hasConcept C86803240 @default.
• W2022237684 hasConceptScore W2022237684C104317684 @default.
• W2022237684 hasConceptScore W2022237684C107824862 @default.
• W2022237684 hasConceptScore W2022237684C181199279 @default.

• next