FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022239213> ?p ?o ?g. }

• W2022239213 endingPage "2279" @default.
• W2022239213 startingPage "2273" @default.
• W2022239213 abstract "Much data have accrued in support of the concept that oxidation of LDL is a key early step in atherogenesis. The most consistent data with respect to micronutrient antioxidants and atherosclerosis appear to relate to alpha-tocopherol (AT), the predominant lipid-soluble antioxidant in LDL. There are scant data on the direct comparison of RRR-AT and all-racemic (rac)-AT on LDL oxidizability. Hence, the aim of the present study was to examine the relative effects of RRR-AT and all-rac-AT on plasma antioxidant levels and LDL oxidation in healthy persons in a dose-response study. The effect of RRR-AT and all-rac-AT at doses of 100, 200, 400, and 800 IU/d on plasma and LDL AT levels and LDL oxidation was tested in a randomized, placebo-controlled study of 79 healthy subjects. Copper-catalyzed oxidation of LDL was monitored by measuring the formation of conjugated dienes and lipid peroxides over an 8-hour time course at baseline and again after 8 weeks. Plasma AT, lipid-standardized AT, and LDL AT levels rose in a dose-dependent fashion in both the RRR-AT and all-rac-AT groups compared with baseline. There were no significant differences in plasma, lipid-standardized, and LDL AT levels between RRR-AT and all-rac-AT supplementation at any dose comparison. The lag phases of oxidation were significantly prolonged with doses > or = 400 IU/d of RRR-AT and all-rac-AT, as measured by conjugated-dienes assay and at 400 IU/d of RRR-AT and 800 IU/d of both forms of AT by lipid peroxide assay. Again, there were no significant differences in the lag phase of oxidation at each dose for RRR-AT when compared with all-rac-AT. Also, there were no significant differences in LDL oxidation after in vitro enrichment of LDL with RRR-AT and all-rac-AT. Thus, supplementation with either RRR-AT or all-rac-AT resulted in similar increases in plasma and LDL AT levels at equivalent IU doses, and the degree of protection against copper-catalyzed LDL oxidation was only evident at doses > or = 400 IU/d for both forms." @default.
• W2022239213 created "2016-06-24" @default.
• W2022239213 creator A5011782005 @default.
• W2022239213 creator A5037796085 @default.
• W2022239213 creator A5081361929 @default.
• W2022239213 creator A5090139389 @default.
• W2022239213 date "1997-10-01" @default.
• W2022239213 modified "2023-09-23" @default.
• W2022239213 title "Dose-Response Comparison of <i>RRR</i> -α-Tocopherol and All-Racemic α-Tocopherol on LDL Oxidation" @default.
• W2022239213 cites W1480402741 @default.
• W2022239213 cites W1583483795 @default.
• W2022239213 cites W1775749144 @default.
• W2022239213 cites W1824334719 @default.
• W2022239213 cites W1841006369 @default.
• W2022239213 cites W1852336787 @default.
• W2022239213 cites W1927755828 @default.
• W2022239213 cites W1968679020 @default.
• W2022239213 cites W1976518583 @default.
• W2022239213 cites W1977778060 @default.
• W2022239213 cites W1981651489 @default.
• W2022239213 cites W1983748680 @default.
• W2022239213 cites W1993000626 @default.
• W2022239213 cites W2000548860 @default.
• W2022239213 cites W2003066854 @default.
• W2022239213 cites W2003182703 @default.
• W2022239213 cites W2009117465 @default.
• W2022239213 cites W2027274190 @default.
• W2022239213 cites W2028364295 @default.
• W2022239213 cites W2029314163 @default.
• W2022239213 cites W2040923416 @default.
• W2022239213 cites W2043948984 @default.
• W2022239213 cites W2050814649 @default.
• W2022239213 cites W2053680041 @default.
• W2022239213 cites W2060256649 @default.
• W2022239213 cites W2060845714 @default.
• W2022239213 cites W2064328290 @default.
• W2022239213 cites W2067462171 @default.
• W2022239213 cites W2078316516 @default.
• W2022239213 cites W2081793507 @default.
• W2022239213 cites W2091037241 @default.
• W2022239213 cites W2099992849 @default.
• W2022239213 cites W2107539572 @default.
• W2022239213 cites W2116828347 @default.
• W2022239213 cites W2147908356 @default.
• W2022239213 cites W2152719764 @default.
• W2022239213 cites W2159858491 @default.
• W2022239213 cites W2329711941 @default.
• W2022239213 cites W2334903440 @default.
• W2022239213 cites W2338916478 @default.
• W2022239213 cites W3022864527 @default.
• W2022239213 cites W4290987751 @default.
• W2022239213 doi "https://doi.org/10.1161/01.atv.17.10.2273" @default.
• W2022239213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9351400" @default.
• W2022239213 hasPublicationYear "1997" @default.
• W2022239213 type Work @default.
• W2022239213 sameAs 2022239213 @default.
• W2022239213 citedByCount "91" @default.
• W2022239213 countsByYear W20222392132012 @default.
• W2022239213 countsByYear W20222392132013 @default.
• W2022239213 countsByYear W20222392132014 @default.
• W2022239213 countsByYear W20222392132015 @default.
• W2022239213 countsByYear W20222392132016 @default.
• W2022239213 countsByYear W20222392132017 @default.
• W2022239213 countsByYear W20222392132020 @default.
• W2022239213 countsByYear W20222392132021 @default.
• W2022239213 crossrefType "journal-article" @default.
• W2022239213 hasAuthorship W2022239213A5011782005 @default.
• W2022239213 hasAuthorship W2022239213A5037796085 @default.
• W2022239213 hasAuthorship W2022239213A5081361929 @default.
• W2022239213 hasAuthorship W2022239213A5090139389 @default.
• W2022239213 hasBestOaLocation W20222392131 @default.
• W2022239213 hasConcept C126322002 @default.
• W2022239213 hasConcept C134018914 @default.
• W2022239213 hasConcept C142724271 @default.
• W2022239213 hasConcept C185592680 @default.
• W2022239213 hasConcept C204787440 @default.
• W2022239213 hasConcept C27081682 @default.
• W2022239213 hasConcept C2777551382 @default.
• W2022239213 hasConcept C2778004101 @default.
• W2022239213 hasConcept C2781449162 @default.
• W2022239213 hasConcept C2994476132 @default.
• W2022239213 hasConcept C3017575891 @default.
• W2022239213 hasConcept C55493867 @default.
• W2022239213 hasConcept C71924100 @default.
• W2022239213 hasConcept C98274493 @default.
• W2022239213 hasConceptScore W2022239213C126322002 @default.
• W2022239213 hasConceptScore W2022239213C134018914 @default.
• W2022239213 hasConceptScore W2022239213C142724271 @default.
• W2022239213 hasConceptScore W2022239213C185592680 @default.
• W2022239213 hasConceptScore W2022239213C204787440 @default.
• W2022239213 hasConceptScore W2022239213C27081682 @default.
• W2022239213 hasConceptScore W2022239213C2777551382 @default.
• W2022239213 hasConceptScore W2022239213C2778004101 @default.
• W2022239213 hasConceptScore W2022239213C2781449162 @default.
• W2022239213 hasConceptScore W2022239213C2994476132 @default.
• W2022239213 hasConceptScore W2022239213C3017575891 @default.
• W2022239213 hasConceptScore W2022239213C55493867 @default.
• W2022239213 hasConceptScore W2022239213C71924100 @default.

• next