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- W2022239470 abstract "We have investigated the effects administering exogenous progesterone, via insertion of a controlled internal drug release (CIDR) for 4 days, from either day 5 or day 12 of the oestrous cycle on plasma oestradiol concentrations. In study 1, in which progesterone was administered from day 5, measurement of plasma oestradiol in daily samples revealed a significant (p < 0.001) decrease in peripheral oestradiol concentration. In contrast, in study 2, similar administration of progesterone from day 12 had no effect on plasma oestradiol concentration. In study 3, collection of hourly samples following progesterone treatment on day 5 revealed peak progesterone concentrations within 1 h of CIDR insertion and nadir oestradiol concentrations within 4 h. The results demonstrate that treatment with progesterone early in the luteal phase causes a rapid inhibition of oestradiol secretion, while later treatment does not. While improvements in pregnancy rate following progesterone treatment at this time have traditionally been attributed to increases in progesterone, the potential involvement of decreased oestradiol secretion has often been overlooked." @default.
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- W2022239470 date "2010-04-01" @default.
- W2022239470 modified "2023-09-26" @default.
- W2022239470 title "Differential Effects of Exogenous Progesterone Administration at Different Stages of the Luteal Phase on Endogenous Oestradiol Concentration in Cows" @default.
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- W2022239470 doi "https://doi.org/10.1111/j.1439-0531.2008.01291.x" @default.
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