FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022241939> ?p ?o ?g. }

• W2022241939 endingPage "3079" @default.
• W2022241939 startingPage "3073" @default.
• W2022241939 abstract "BACKGROUNDBreast carcinoma is moderately sensitive to multiple antitumor agents. Cytotoxic combination regimens developed in the 1970s were shown to produce higher response rates and longer durations of response and survival than single-agent therapy. These regimens became the standard of care for the management of metastatic, hormone-refractory breast carcinoma, and more recently, for primary breast carcinoma. Randomized trials also have demonstrated that amthracycline-containing combinations were more effective than combinations without anthracyclines. The development of several new cytotoxic agents and novel antitumor strategies prompted this review.METHODSThe author conducted a computerized literature search of MEDLINE and CANCERLIT and also reviewed the abstracts of major oncology meetings (ASCO, American Association for Cancer Research, ESMO, and San Antonio Breast Cancer Symposium) over the past 10 years.RESULTSEffective new cytotoxic drugs include the taxanes (paclitaxel and docetaxel), vinorelbine, gemcitabine, and capecitabine. The identification of specific molecular abnormalities (HER-2/neu or epidermal growth factor receptor [EGFR] overexpression) led to the development of targeted therapeutic intervention (monoclonal antibodies and tyrosine kinase inhibitors). Trastuzumab, a monoclonal antibody against the HER-2/neu oncoprotein, produced objective regression in 15–20% of patients with HER-2/neu–overexpressing breast carcinoma and improved the efficacy of paclitaxel. Other productive directions of therapeutic research include inhibition of intracellular signaling, interference with tumor angiogenesis, cell cycle regulation, and the development of vaccines.CONCLUSIONSExpanded understanding of the biology of breast carcinoma led to the development of rational therapeutic interventions, many of which are currently under active clinical development. Cancer 2000;88:3073–9. © 2000 American Cancer Society." @default.
• W2022241939 created "2016-06-24" @default.
• W2022241939 creator A5018617106 @default.
• W2022241939 date "2000-06-15" @default.
• W2022241939 modified "2023-09-25" @default.
• W2022241939 title "Developments in chemotherapy of breast cancer" @default.
• W2022241939 cites W1262485082 @default.
• W2022241939 cites W1521419744 @default.
• W2022241939 cites W1522722282 @default.
• W2022241939 cites W1812067939 @default.
• W2022241939 cites W1841504999 @default.
• W2022241939 cites W1846747462 @default.
• W2022241939 cites W1890813079 @default.
• W2022241939 cites W1899541887 @default.
• W2022241939 cites W1929485622 @default.
• W2022241939 cites W1939003096 @default.
• W2022241939 cites W1955744924 @default.
• W2022241939 cites W1965629926 @default.
• W2022241939 cites W1968785826 @default.
• W2022241939 cites W1973286526 @default.
• W2022241939 cites W1974513579 @default.
• W2022241939 cites W1978072892 @default.
• W2022241939 cites W1984457590 @default.
• W2022241939 cites W1985385381 @default.
• W2022241939 cites W1993294872 @default.
• W2022241939 cites W1999087253 @default.
• W2022241939 cites W2003071454 @default.
• W2022241939 cites W2008096556 @default.
• W2022241939 cites W2020804350 @default.
• W2022241939 cites W2023779015 @default.
• W2022241939 cites W2024841231 @default.
• W2022241939 cites W2035881635 @default.
• W2022241939 cites W2039642936 @default.
• W2022241939 cites W2045264832 @default.
• W2022241939 cites W2050062541 @default.
• W2022241939 cites W2050831507 @default.
• W2022241939 cites W2066465524 @default.
• W2022241939 cites W2071680349 @default.
• W2022241939 cites W2071852676 @default.
• W2022241939 cites W2078783773 @default.
• W2022241939 cites W2079870631 @default.
• W2022241939 cites W2080391833 @default.
• W2022241939 cites W2095259252 @default.
• W2022241939 cites W2095632857 @default.
• W2022241939 cites W2101100140 @default.
• W2022241939 cites W2116398087 @default.
• W2022241939 cites W2150974445 @default.
• W2022241939 cites W2154027407 @default.
• W2022241939 cites W2169073956 @default.
• W2022241939 cites W2171691777 @default.
• W2022241939 cites W2214029008 @default.
• W2022241939 cites W2253920138 @default.
• W2022241939 cites W2270490184 @default.
• W2022241939 cites W2279916335 @default.
• W2022241939 cites W2319962899 @default.
• W2022241939 cites W2339705539 @default.
• W2022241939 cites W2367472947 @default.
• W2022241939 cites W2414775011 @default.
• W2022241939 cites W4233628679 @default.
• W2022241939 cites W43791037 @default.
• W2022241939 doi "https://doi.org/10.1002/1097-0142(20000615)88:12+<3073::aid-cncr26>3.0.co;2-r" @default.
• W2022241939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10898354" @default.
• W2022241939 hasPublicationYear "2000" @default.
• W2022241939 type Work @default.
• W2022241939 sameAs 2022241939 @default.
• W2022241939 citedByCount "72" @default.
• W2022241939 countsByYear W20222419392012 @default.
• W2022241939 countsByYear W20222419392013 @default.
• W2022241939 countsByYear W20222419392014 @default.
• W2022241939 countsByYear W20222419392015 @default.
• W2022241939 countsByYear W20222419392016 @default.
• W2022241939 countsByYear W20222419392017 @default.
• W2022241939 crossrefType "journal-article" @default.
• W2022241939 hasAuthorship W2022241939A5018617106 @default.
• W2022241939 hasConcept C121608353 @default.
• W2022241939 hasConcept C126322002 @default.
• W2022241939 hasConcept C143998085 @default.
• W2022241939 hasConcept C2776694085 @default.
• W2022241939 hasConcept C29456083 @default.
• W2022241939 hasConcept C530470458 @default.
• W2022241939 hasConcept C71924100 @default.
• W2022241939 hasConceptScore W2022241939C121608353 @default.
• W2022241939 hasConceptScore W2022241939C126322002 @default.
• W2022241939 hasConceptScore W2022241939C143998085 @default.
• W2022241939 hasConceptScore W2022241939C2776694085 @default.
• W2022241939 hasConceptScore W2022241939C29456083 @default.
• W2022241939 hasConceptScore W2022241939C530470458 @default.
• W2022241939 hasConceptScore W2022241939C71924100 @default.
• W2022241939 hasIssue "S12" @default.
• W2022241939 hasLocation W20222419391 @default.
• W2022241939 hasOpenAccess W2022241939 @default.
• W2022241939 hasPrimaryLocation W20222419391 @default.
• W2022241939 hasRelatedWork W2348231456 @default.
• W2022241939 hasRelatedWork W2354050160 @default.
• W2022241939 hasRelatedWork W2367105124 @default.
• W2022241939 hasRelatedWork W2368979736 @default.
• W2022241939 hasRelatedWork W2369039771 @default.
• W2022241939 hasRelatedWork W2379009234 @default.

• next