Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022243398> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2022243398 endingPage "138" @default.
- W2022243398 startingPage "135" @default.
- W2022243398 abstract "Magainins are a family of antimicrobial peptides present in the skin extracts of Xenopus laevis. Both magainin-1 and -2 do not have any significant effect on the activity of protein kinase C (PKC). Magainin-2 was found to be readily phosphorylated by PKC to 0.5 mol 32P/mol of peptide. Neither magainin-1, which has a sequence of S8AGK and not S8AKK as in the case of magainin-2, nor the magainin-2 analogue with substitution of Ala for Ser8 was phosphorylated by the kinase, suggesting that Ser8 is the phosphorylation site of magainin-2. One synthetic analogue of magainin, designated magainin B, which has a greater tendency for alpha-helix formation in non-aqueous environment than the parent peptide resulting from substitution of Ser8, Gly13, and Gly18 with Ala in magainin-2-amide, is a potent inhibitor of PKC. This peptide inhibits all three PKC isozymes with IC50 less than 20 microM. Magainin B also inhibits the binding of [3H]phorbol 12,13-dibutyrate to the kinase. These results suggest that magainin-2 may be modified by PKC through phosphorylation and that certain synthetic analogues of magainins may be used as inhibitors of PKC." @default.
- W2022243398 created "2016-06-24" @default.
- W2022243398 creator A5042715380 @default.
- W2022243398 creator A5046614381 @default.
- W2022243398 creator A5062395164 @default.
- W2022243398 creator A5069641243 @default.
- W2022243398 creator A5078318819 @default.
- W2022243398 date "1990-07-02" @default.
- W2022243398 modified "2023-09-25" @default.
- W2022243398 title "Phosphorylation of magainin-2 by protein kinase C and inhibition of protein kinase C isozymes by a synthetic analogue of magainin-2-amide" @default.
- W2022243398 cites W1486015064 @default.
- W2022243398 cites W1605748290 @default.
- W2022243398 cites W1608575135 @default.
- W2022243398 cites W1964839077 @default.
- W2022243398 cites W2004107464 @default.
- W2022243398 cites W2005870566 @default.
- W2022243398 cites W2013092938 @default.
- W2022243398 cites W2013100512 @default.
- W2022243398 cites W2016243005 @default.
- W2022243398 cites W2033415985 @default.
- W2022243398 cites W2049192006 @default.
- W2022243398 cites W2056570185 @default.
- W2022243398 cites W2072436875 @default.
- W2022243398 cites W2077686814 @default.
- W2022243398 cites W2079468421 @default.
- W2022243398 cites W2083450933 @default.
- W2022243398 cites W2223822401 @default.
- W2022243398 doi "https://doi.org/10.1016/0014-5793(90)80307-5" @default.
- W2022243398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2365080" @default.
- W2022243398 hasPublicationYear "1990" @default.
- W2022243398 type Work @default.
- W2022243398 sameAs 2022243398 @default.
- W2022243398 citedByCount "12" @default.
- W2022243398 countsByYear W20222433982014 @default.
- W2022243398 crossrefType "journal-article" @default.
- W2022243398 hasAuthorship W2022243398A5042715380 @default.
- W2022243398 hasAuthorship W2022243398A5046614381 @default.
- W2022243398 hasAuthorship W2022243398A5062395164 @default.
- W2022243398 hasAuthorship W2022243398A5069641243 @default.
- W2022243398 hasAuthorship W2022243398A5078318819 @default.
- W2022243398 hasBestOaLocation W20222433981 @default.
- W2022243398 hasConcept C11960822 @default.
- W2022243398 hasConcept C153911025 @default.
- W2022243398 hasConcept C184235292 @default.
- W2022243398 hasConcept C185592680 @default.
- W2022243398 hasConcept C195794163 @default.
- W2022243398 hasConcept C2778553168 @default.
- W2022243398 hasConcept C2779281246 @default.
- W2022243398 hasConcept C540938839 @default.
- W2022243398 hasConcept C55493867 @default.
- W2022243398 hasConcept C86803240 @default.
- W2022243398 hasConcept C97029542 @default.
- W2022243398 hasConceptScore W2022243398C11960822 @default.
- W2022243398 hasConceptScore W2022243398C153911025 @default.
- W2022243398 hasConceptScore W2022243398C184235292 @default.
- W2022243398 hasConceptScore W2022243398C185592680 @default.
- W2022243398 hasConceptScore W2022243398C195794163 @default.
- W2022243398 hasConceptScore W2022243398C2778553168 @default.
- W2022243398 hasConceptScore W2022243398C2779281246 @default.
- W2022243398 hasConceptScore W2022243398C540938839 @default.
- W2022243398 hasConceptScore W2022243398C55493867 @default.
- W2022243398 hasConceptScore W2022243398C86803240 @default.
- W2022243398 hasConceptScore W2022243398C97029542 @default.
- W2022243398 hasIssue "1" @default.
- W2022243398 hasLocation W20222433981 @default.
- W2022243398 hasLocation W20222433982 @default.
- W2022243398 hasOpenAccess W2022243398 @default.
- W2022243398 hasPrimaryLocation W20222433981 @default.
- W2022243398 hasRelatedWork W2025409136 @default.
- W2022243398 hasRelatedWork W2030910709 @default.
- W2022243398 hasRelatedWork W2033498478 @default.
- W2022243398 hasRelatedWork W2062521580 @default.
- W2022243398 hasRelatedWork W2162618593 @default.
- W2022243398 hasRelatedWork W227918356 @default.
- W2022243398 hasRelatedWork W2382491703 @default.
- W2022243398 hasRelatedWork W2410202282 @default.
- W2022243398 hasRelatedWork W2916357899 @default.
- W2022243398 hasRelatedWork W2136545008 @default.
- W2022243398 hasVolume "267" @default.
- W2022243398 isParatext "false" @default.
- W2022243398 isRetracted "false" @default.
- W2022243398 magId "2022243398" @default.
- W2022243398 workType "article" @default.