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- W2022244225 abstract "Purpose Patterns of weight change following implantation of continuous flow LVADs (CF LVADs) affect transplant candidacy and contribute to adverse outcomes and survival. We evaluated changes in weight over a 24 month period in a large LVAD clinical trial database. Methods and Materials A retrospective analysis of 896 patients enrolled in the HeartMate II Clinical trials for bridge to transplant and destination therapy from March 2005 - January 2009 was performed. Patients were divided into 4 groups: underweight (UW: body mass index (BMI) 2 ]), normal (NM:18.5-30), obese (OB:30-35), and morbidly obese (MO>35). BMI was analyzed at 6 month intervals through 24 months (linear mixed effects modeling). Pre-albumin levels were also determined. Results At 6 months there were significant changes in BMI (p 10%. Pre-albumin trended up at 6 months (18.4±7.2 vs. 22.8±6.9, p NS) and remained stable at 24 months with no intergroup differences. Intragroup changes were significant. Download high-res image (40KB) Download full-size image Table 1 . Pre-Albumin Changes Group Baseline 6 Months P Value BMI 15.2±5.4 21.8±7.5 0.001 18.5≤BMI 18.2±7.5 22.8±6.8 30≤BMI 19.3±7.3 22.5±7.4 0.007 BMI≥35 17.6±6.9 22.5±6.8 0.001 Conclusions The lowest BMI patients gain weight to normal ranges during CF LVAD support. OB and MO patients stay within 10% of baseline weight. 1 in 5 lose more than 10%. Nutritional status improves in all groups. Aggressive weight control strategies (e.g. bariatric surgery referral) should be considered and emphasized in CF LVAD patients." @default.
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- W2022244225 date "2011-04-01" @default.
- W2022244225 modified "2023-09-26" @default.
- W2022244225 title "73 Patients with Low Compared to High Body Mass Index Gain More Weight after Continuous Flow LVAD Implant" @default.
- W2022244225 doi "https://doi.org/10.1016/j.healun.2011.01.080" @default.
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