Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022246541> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2022246541 endingPage "985" @default.
- W2022246541 startingPage "982" @default.
- W2022246541 abstract "Proteinuria in children with sickle cell anemia (SCA) is an early sign of sickle nephropathy, and portends the development of nephrotic syndrome and chronic renal failure. Enalapril has been shown to reduce proteinuria in adult patients with SCA, but the potential benefits of hydroxyurea in this clinical setting have not been reported. A single institution retrospective analysis was performed. Children with sickle nephropathy were identified, and the laboratory effects of enalapril and hydroxyurea therapy were evaluated in children with substantial proteinuria. Three children developed proteinuria at 8 +/- 1 years of age. Pre-treatment laboratory studies included a low serum albumin (2.8 +/- 0.8 g/dl) and a highly elevated urine protein/creatinine ratio (6.9 +/- 3.7, normal <0.2). Enalapril treatment for 3.0 +/- 1.3 years normalized serum albumin (3.9 +/- 0.3 g/dl) without significant changes in serum potassium, serum creatinine, or systolic blood pressure. However, urine protein/creatinine remained elevated in the nephrotic range (1.6 +/- 0.7). The addition of hydroxyurea therapy for 3.5 +/- 1.2 years increased fetal hemoglobin levels (7.0 +/- 3.6% to 21.0 +/- 3.2%) and was associated with a near-normal urine protein/creatinine ratio (0.5 +/- 0.1). Enalapril therapy for children with sickle nephropathy reduces urinary protein excretion and normalizes serum albumin. Hydroxyurea therapy may further normalize the urine protein/creatinine ratio. Combination therapy should be tested prospectively in children with sickle nephropathy." @default.
- W2022246541 created "2016-06-24" @default.
- W2022246541 creator A5040752648 @default.
- W2022246541 creator A5066283756 @default.
- W2022246541 creator A5087536541 @default.
- W2022246541 date "2005-01-01" @default.
- W2022246541 modified "2023-10-13" @default.
- W2022246541 title "Enalapril and hydroxyurea therapy for children with sickle nephropathy" @default.
- W2022246541 cites W1548270617 @default.
- W2022246541 cites W1963802507 @default.
- W2022246541 cites W1971614054 @default.
- W2022246541 cites W1989590429 @default.
- W2022246541 cites W2028649480 @default.
- W2022246541 cites W2030113557 @default.
- W2022246541 cites W2030200578 @default.
- W2022246541 cites W2036592550 @default.
- W2022246541 cites W2049661833 @default.
- W2022246541 cites W2055567310 @default.
- W2022246541 cites W2090081604 @default.
- W2022246541 cites W2093626328 @default.
- W2022246541 cites W2313541759 @default.
- W2022246541 cites W2318152682 @default.
- W2022246541 cites W2332473024 @default.
- W2022246541 cites W2334263927 @default.
- W2022246541 doi "https://doi.org/10.1002/pbc.20296" @default.
- W2022246541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15704213" @default.
- W2022246541 hasPublicationYear "2005" @default.
- W2022246541 type Work @default.
- W2022246541 sameAs 2022246541 @default.
- W2022246541 citedByCount "87" @default.
- W2022246541 countsByYear W20222465412012 @default.
- W2022246541 countsByYear W20222465412013 @default.
- W2022246541 countsByYear W20222465412014 @default.
- W2022246541 countsByYear W20222465412015 @default.
- W2022246541 countsByYear W20222465412016 @default.
- W2022246541 countsByYear W20222465412017 @default.
- W2022246541 countsByYear W20222465412018 @default.
- W2022246541 countsByYear W20222465412019 @default.
- W2022246541 countsByYear W20222465412020 @default.
- W2022246541 countsByYear W20222465412021 @default.
- W2022246541 countsByYear W20222465412022 @default.
- W2022246541 countsByYear W20222465412023 @default.
- W2022246541 crossrefType "journal-article" @default.
- W2022246541 hasAuthorship W2022246541A5040752648 @default.
- W2022246541 hasAuthorship W2022246541A5066283756 @default.
- W2022246541 hasAuthorship W2022246541A5087536541 @default.
- W2022246541 hasConcept C126322002 @default.
- W2022246541 hasConcept C126894567 @default.
- W2022246541 hasConcept C134018914 @default.
- W2022246541 hasConcept C159641895 @default.
- W2022246541 hasConcept C27016395 @default.
- W2022246541 hasConcept C2775940317 @default.
- W2022246541 hasConcept C2778930706 @default.
- W2022246541 hasConcept C2779561371 @default.
- W2022246541 hasConcept C2780091579 @default.
- W2022246541 hasConcept C2780306776 @default.
- W2022246541 hasConcept C2781184683 @default.
- W2022246541 hasConcept C555293320 @default.
- W2022246541 hasConcept C71924100 @default.
- W2022246541 hasConcept C84393581 @default.
- W2022246541 hasConcept C90924648 @default.
- W2022246541 hasConceptScore W2022246541C126322002 @default.
- W2022246541 hasConceptScore W2022246541C126894567 @default.
- W2022246541 hasConceptScore W2022246541C134018914 @default.
- W2022246541 hasConceptScore W2022246541C159641895 @default.
- W2022246541 hasConceptScore W2022246541C27016395 @default.
- W2022246541 hasConceptScore W2022246541C2775940317 @default.
- W2022246541 hasConceptScore W2022246541C2778930706 @default.
- W2022246541 hasConceptScore W2022246541C2779561371 @default.
- W2022246541 hasConceptScore W2022246541C2780091579 @default.
- W2022246541 hasConceptScore W2022246541C2780306776 @default.
- W2022246541 hasConceptScore W2022246541C2781184683 @default.
- W2022246541 hasConceptScore W2022246541C555293320 @default.
- W2022246541 hasConceptScore W2022246541C71924100 @default.
- W2022246541 hasConceptScore W2022246541C84393581 @default.
- W2022246541 hasConceptScore W2022246541C90924648 @default.
- W2022246541 hasIssue "7" @default.
- W2022246541 hasLocation W20222465411 @default.
- W2022246541 hasLocation W20222465412 @default.
- W2022246541 hasOpenAccess W2022246541 @default.
- W2022246541 hasPrimaryLocation W20222465411 @default.
- W2022246541 hasRelatedWork W20644872 @default.
- W2022246541 hasRelatedWork W2089052995 @default.
- W2022246541 hasRelatedWork W2371727475 @default.
- W2022246541 hasRelatedWork W2372234355 @default.
- W2022246541 hasRelatedWork W2393969501 @default.
- W2022246541 hasRelatedWork W2397846374 @default.
- W2022246541 hasRelatedWork W2398998059 @default.
- W2022246541 hasRelatedWork W2405610365 @default.
- W2022246541 hasRelatedWork W2473319833 @default.
- W2022246541 hasRelatedWork W2507318694 @default.
- W2022246541 hasVolume "45" @default.
- W2022246541 isParatext "false" @default.
- W2022246541 isRetracted "false" @default.
- W2022246541 magId "2022246541" @default.
- W2022246541 workType "article" @default.