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• W2022246592 abstract "Propos. – Différents arguments d'ordre conceptuel, épidémiologique et économique ainsi que la fréquence des polypathologies ont conduit à limiter la prise en charge médicamenteuse de l'hypercholestérolémie chez la personne âgée. Actualités et points forts. – Longtemps délaissées par les grands essais thérapeutiques ayant démontré l'intérêt des statines dans la réduction de la morbi-mortalité cardiovasculaire, les personnes âgées sont pourtant les plus fréquemment concernées par ces affections. En réalité des études récentes démontrent que l'effet des statines n'est pas diminué chez la personne âgée de plus de 65 ans. Les statines réduisent le risque relatif de la mortalité globale et cardiovasculaire ainsi que des événements coronariens et des accidents vasculaires cérébraux et ce, quelle que soit la concentration du cholestérol LDL. La tolérance n'est pas différente que chez les sujets plus jeunes. Perspectives. – Toutefois, les données disponibles chez les sujets de plus de 80 ans sont encore peu nombreuses. Il semble actuellement licite de prescrire une statine lorsque la concentration de cholestérol LDL est supérieure à 1,30 g/l chez un sujet âgé à haut risque cardiovasculaire ou en prévention secondaire dès lors que son espérance de vie est conséquente. Introduction. – The rationale for the treatment of hypercholesterolemia in the elderly is less clear than in middle-aged patients because of several conceptual, epidemiological, economical facts, a higher prevalence of polypathology and a weaker relation between hypercholesterolemia and cardiovascular risk when age increases. Current knowledge and key points. – However, cardiovascular events-stroke and myocardial infarction occur mainly in people aged more than 65 years. The data of recent randomised clinical trials have demonstrated that the use of statins in the elderly remained associated to a reduced all-cause mortality, cardiovascular mortality and stroke. Statins were effective in elderly with average LDL-cholesterol in primary and secondary prevention trials. The drug tolerance was as good as in middle-aged patients. However, convincing data concerning subjects over 80 are lacking. Conclusion. – On the basis of disponible data it may be considered that statins are useful in older persons with a serum LDL cholesterol level above 1.3 g/l and or a high cardiovascular risk, with or without cardiovascular disease, when their life expectancy is consequent." @default.
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• W2022246592 date "2004-11-01" @default.
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• W2022246592 title "Statines et risque cérébro- et cardiovasculaire chez les personnes âgées" @default.
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