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- W2022248217 abstract "Previous studies have shown p53 germ-line mutations in some familial cancer aggregations with or without the Li-Fraumeni syndrome (LFS). Such mutations were also reported in children and young adults with second malignant neoplasms (SMN). This led us to screen for p53 germ-line mutations in a group of seven patients affected with SMN, but characterized by an older age of onset than in the previous reports. No mutation was found in exons 4 to 8 and their boundaries using the single-strand conformation polymorphism technique. Our results give strong evidence for genetic heterogeneity of SMN, probably related to the age of cancer onset." @default.
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- W2022248217 date "2007-09-01" @default.
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- W2022248217 title "1420 POSTER Sweeping beam total body irradiation in Chile: technical description and clinical results" @default.
- W2022248217 doi "https://doi.org/10.1016/s1359-6349(07)70759-0" @default.
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