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- W2022248576 abstract "Immunoregulatory activity of type I interferons (IFNs) and estrogen is convergent in some cases of autoimmune disorders. The aim of our study was to determine whether a potent interaction of IFN and estradiol (E2) has an influence on immune response and estrogen receptor alpha (ER-α) expression in antigen-presenting cells in a model of experimental autoimmune orchitis (EAO). C3H/He/W male mice were immunized with testicular germ cells (TGCs) and orally treated with interferon tau (IFN-τ), E2, or both simultaneously. The delayed-type hypersensitivity reaction was intensified after the administration of either IFN-τ or E2, but their co-administration had no effect. IFN-τ treatment increased immunoglobulin G2a (IgG2a) and decreased IgG1 levels of TGC-specific antibodies, whereas E2 abolished the effects of the used cytokine. The total splenic cellularity and the number of spleen CD11c+MHC II+ and F4/80+MHC II− cells were increased after IFN-τ treatment, whereas E2 antagonized this effect. After IFN-τ adminis..." @default.
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- W2022248576 date "2011-11-01" @default.
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- W2022248576 title "17β-Estradiol and Interferon Tau Interact in the Regulation of the Immune Response in a Model of Experimental Autoimmune Orchitis" @default.
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- W2022248576 doi "https://doi.org/10.1089/jir.2010.0147" @default.
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