Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022248730> ?p ?o ?g. }
- W2022248730 endingPage "563" @default.
- W2022248730 startingPage "549" @default.
- W2022248730 abstract "Amplified in breast cancer 1 (AIB1) (also known as steroid receptor coactivator-3) is a nuclear receptor coactivator enhancing estrogen receptor (ER)α and progesterone receptor (PR)-dependent transcription in breast cancer. The splice variant AIB1Δ3 demonstrates increased ability to promote ERα and PR-dependent transcription. Both are implicated in breast cancer risk and antihormone resistance. Conditional transgenic mice tested the in vivo impact of AIB1Δ3 overexpression compared with AIB1 on histological features of increased breast cancer risk and growth response to estrogen and progesterone in the mammary gland. Combining expression of either AIB1 or AIB1Δ3 with ERα overexpression, we investigated in vivo cooperativity. AIB1 and AIB1Δ3 overexpression equivalently increased the prevalence of hyperplastic alveolar nodules but not ductal hyperplasia or collagen content. When AIB1 or AIB1Δ3 overexpression was combined with ERα, both stromal collagen content and ductal hyperplasia prevalence were significantly increased and adenocarcinomas appeared. Overexpression of AIB1Δ3, especially combined with overexpressed ERα, led to an abnormal response to estrogen and progesterone with significant increases in stromal collagen content and development of a multilayered mammary epithelium. AIB1Δ3 overexpression was associated with a significant increase in PR expression and PR downstream signaling genes. AIB1 overexpression produced less marked growth abnormalities and no significant change in PR expression. In summary, AIB1Δ3 overexpression was more potent than AIB1 overexpression in increasing stromal collagen content, inducing abnormal mammary epithelial growth, altering PR expression levels, and mediating the response to estrogen and progesterone. Combining ERα overexpression with either AIB1 or AIB1Δ3 overexpression augmented abnormal growth responses in both epithelial and stromal compartments." @default.
- W2022248730 created "2016-06-24" @default.
- W2022248730 creator A5023506665 @default.
- W2022248730 creator A5036554782 @default.
- W2022248730 creator A5040868176 @default.
- W2022248730 creator A5050665929 @default.
- W2022248730 creator A5053625755 @default.
- W2022248730 creator A5059102143 @default.
- W2022248730 creator A5085158813 @default.
- W2022248730 creator A5089837987 @default.
- W2022248730 date "2011-04-01" @default.
- W2022248730 modified "2023-10-06" @default.
- W2022248730 title "Altered AIB1 or AIB1Δ3 Expression Impacts ERα Effects on Mammary Gland Stromal and Epithelial Content" @default.
- W2022248730 cites W1566835344 @default.
- W2022248730 cites W1593442063 @default.
- W2022248730 cites W1925039551 @default.
- W2022248730 cites W1964456768 @default.
- W2022248730 cites W1966972759 @default.
- W2022248730 cites W1973321155 @default.
- W2022248730 cites W1975612635 @default.
- W2022248730 cites W1976439844 @default.
- W2022248730 cites W1977027014 @default.
- W2022248730 cites W1978128491 @default.
- W2022248730 cites W1984237191 @default.
- W2022248730 cites W1984433201 @default.
- W2022248730 cites W1985193538 @default.
- W2022248730 cites W1987556047 @default.
- W2022248730 cites W1990529844 @default.
- W2022248730 cites W1992657457 @default.
- W2022248730 cites W2000011119 @default.
- W2022248730 cites W2005242533 @default.
- W2022248730 cites W2005973091 @default.
- W2022248730 cites W2006156098 @default.
- W2022248730 cites W2014115970 @default.
- W2022248730 cites W2016484184 @default.
- W2022248730 cites W2017581146 @default.
- W2022248730 cites W2019004723 @default.
- W2022248730 cites W2019380047 @default.
- W2022248730 cites W2030954815 @default.
- W2022248730 cites W2032210749 @default.
- W2022248730 cites W2033430640 @default.
- W2022248730 cites W2039895542 @default.
- W2022248730 cites W2040361144 @default.
- W2022248730 cites W2040371661 @default.
- W2022248730 cites W2041492502 @default.
- W2022248730 cites W2045196697 @default.
- W2022248730 cites W2046194218 @default.
- W2022248730 cites W2049786577 @default.
- W2022248730 cites W2050868693 @default.
- W2022248730 cites W2055931088 @default.
- W2022248730 cites W2058959360 @default.
- W2022248730 cites W2060123703 @default.
- W2022248730 cites W2060128629 @default.
- W2022248730 cites W2060378662 @default.
- W2022248730 cites W2061221413 @default.
- W2022248730 cites W2062809449 @default.
- W2022248730 cites W2064956340 @default.
- W2022248730 cites W2071885331 @default.
- W2022248730 cites W2076624144 @default.
- W2022248730 cites W2079313268 @default.
- W2022248730 cites W2081218744 @default.
- W2022248730 cites W2088641580 @default.
- W2022248730 cites W2090429649 @default.
- W2022248730 cites W2097134216 @default.
- W2022248730 cites W2103791567 @default.
- W2022248730 cites W2104200252 @default.
- W2022248730 cites W2105985632 @default.
- W2022248730 cites W2108184788 @default.
- W2022248730 cites W2109388713 @default.
- W2022248730 cites W2109994415 @default.
- W2022248730 cites W2110279965 @default.
- W2022248730 cites W2111319976 @default.
- W2022248730 cites W2113227671 @default.
- W2022248730 cites W2114570899 @default.
- W2022248730 cites W2116983326 @default.
- W2022248730 cites W2117963341 @default.
- W2022248730 cites W2125066552 @default.
- W2022248730 cites W2126137648 @default.
- W2022248730 cites W2128488710 @default.
- W2022248730 cites W2129132018 @default.
- W2022248730 cites W2131782933 @default.
- W2022248730 cites W2133135729 @default.
- W2022248730 cites W2133244267 @default.
- W2022248730 cites W2134310407 @default.
- W2022248730 cites W2134338342 @default.
- W2022248730 cites W2136737404 @default.
- W2022248730 cites W2143283599 @default.
- W2022248730 cites W2143745813 @default.
- W2022248730 cites W2149120477 @default.
- W2022248730 cites W2153864725 @default.
- W2022248730 cites W2155412740 @default.
- W2022248730 cites W2155533879 @default.
- W2022248730 cites W2155556340 @default.
- W2022248730 cites W2156016303 @default.
- W2022248730 cites W2157477417 @default.
- W2022248730 cites W2159610509 @default.
- W2022248730 cites W2161506868 @default.
- W2022248730 cites W2167787018 @default.