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- W2022249912 abstract "1 The effect of amphetamine on the secretion of testosterone and the production of testicular adenosine 3′:5′-cyclic monophosphate (cyclic AMP) in rats was studied. 2 A single intravenous injection of amphetamine decreased the basal and human chorionic gonadotropin (hCG)-stimulated levels of plasma testosterone. Plasma LH levels were not altered by the injection of amphetamine. 3 Administration of amphetamine in vitro resulted in a dose-dependent inhibition of both basal and hCG-stimulated release of testosterone. 4 Amphetamine enhanced the basal and hCG-increased levels of cyclic AMP accumulation in vitro in rat testes. 5 These results suggest that amphetamine inhibits the spontaneous and hCG-stimulated secretion of testosterone from the testes through a mechanism involving an increase in cyclic AMP production." @default.
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- W2022249912 date "1996-06-01" @default.
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- W2022249912 title "Inhibition by amphetamine of testosterone secretion through a mechanism involving an increase of cyclic AMP production in rat testes" @default.
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