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• W2022251057 abstract "In antiphospholipid syndrome (APS) the presence of anti-β 2 -glycoprotein I (β 2 GPI) antibodies is strongly associated with thromboembolic complications. It has been suggested that the common β 2 GPI Valine/Leucine 247 (Val/Leu 247 )polymorphism could be found more commonly in APS and might influence the generation of anti-β 2 GPI antibodies. Therefore we studied β 2 GPI Val/Leu 247 single-nucleotide polymorphism (SNP) by PCR in 338 patients with various autoimmune diseases (46 with secondary and 84 with primary APS) and 147 sex and age-matched healthy controls. In all patients lupus anticoagulant, anticardiolipin and anti-β 2 GPI antibodies (both IgG and IgM) were also determined. All patients and controls were Caucasians. Frequencies of the SNP genotypes in patients did not depart from genetic equilibrum and did not differ from those found in controls. There was also no association between the presence of β 2 GPI Val/Leu 247 genotypes and the presence or absence of lupus anticoagulant, anticardiolipin antibodies, anti-β 2 GPI antibodies or clinical APS symptoms in all patients studied. In conclusion, among the exclusively Caucasian, Polish population of autoimmune patients β 2 GPI Val/Leu 247 SNP has the same distribution as in healthy subjects and does not influence the production of anti-β 2 GPI antibodies." @default.
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• W2022251057 date "2006-04-01" @default.
• W2022251057 modified "2023-10-17" @default.
• W2022251057 title "Valine/Leucine247 polymorphism of β2-glycoprotein I in patients with antiphospholipid syndrome: lack of association with anti-β2-glycoprotein I antibodies" @default.
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• W2022251057 doi "https://doi.org/10.1191/0961203306lu2288oa" @default.
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