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- W2022251261 abstract "IgG levels were determined on undiluted cerebrospinal fluid (CSF) of 12 patients with active central nervous system lupus (CNS-SLE), 5 patients with SLE without CNS symptoms, 1 patient in remission of CNS-SLE, and 22 normals using a new solid-phase radioimmunoassay. The mean value for IgG was significantly low in the patients with active CNS-SLE when compared with normals, SLE patients without CNS involvement, and the one patient in remission (whose initial value at the onset of the acute phase was low). Although some values for IgG in the active CNS-SLE group were within or higher than the normal range, every patient in this group had significantly low IgG at some time during the acute phase of disease. Serum IgG levels in all patients with SLE, with and without CNS involvement, were normal to high normal. There appears to be no relationship between serum and CSF IgG levels in active CNS-SLE. Microquantitation of CSF IgG levels is more feasible for many laboratories than assay of C4 levels and promises to become a useful tool in differentiating between CNS-SLE and other causes of CNS symtomatology such as steroid-induced encephalopathy." @default.
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- W2022251261 date "1972-10-01" @default.
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- W2022251261 title "IgG levels in cerebrospinal fluid of patients with central nervous system manifestations of systemic lupus erythematosus" @default.
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- W2022251261 doi "https://doi.org/10.1016/0090-1229(72)90002-5" @default.
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