FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022251390> ?p ?o ?g. }

• W2022251390 endingPage "684" @default.
• W2022251390 startingPage "675" @default.
• W2022251390 abstract "To investigate the potential of targeted MR signal amplification strategy for imaging of EGF receptor variant III (EGFRvIII) overexpression associated with the infiltrating margin of aggressive orthotopic brain tumors.F(ab')2 fragments of humanized anti-EGFRvIII monoclonal antibody (EMD72000) were linked to deglycosylated horseradish peroxidase (HRP) and glucose oxidase (GOX). Detection of the F(ab')2 conjugate pair colocalization in vivo was enabled by a subsequent IV injection of a low molecular weight paramagnetic substrate of HRP, diTyr-GdDTPA.The delivery of the targeted fragments to the tumor was validated using SPECT/CT imaging of radiolabeled anti-EGFRvIII F(ab')2 conjugates. Further, by using 3 T MRI, we observed time-dependent differences in tumor signal intensity and signal retention at the endpoint depending on whether or not the animals were pre-injected with the anti-EGFRvIII F(ab')2 conjugates.Imaging of EGFRvIII expression in vivo was enabled by consecutive administration of targeted F(ab')2 conjugates and a paramagnetic substrate resulting in a tumor-specific receptor detection with high specificity and resolution." @default.
• W2022251390 created "2016-06-24" @default.
• W2022251390 creator A5017592912 @default.
• W2022251390 creator A5035945225 @default.
• W2022251390 creator A5042088122 @default.
• W2022251390 date "2013-06-04" @default.
• W2022251390 modified "2023-10-14" @default.
• W2022251390 title "MR Signal Amplification for Imaging of the Mutant EGF Receptor in Orthotopic Human Glioma Model" @default.
• W2022251390 cites W104508307 @default.
• W2022251390 cites W1972655588 @default.
• W2022251390 cites W1975655522 @default.
• W2022251390 cites W1996001139 @default.
• W2022251390 cites W2003569476 @default.
• W2022251390 cites W2008813039 @default.
• W2022251390 cites W2013878898 @default.
• W2022251390 cites W2036614632 @default.
• W2022251390 cites W2039964383 @default.
• W2022251390 cites W2043445996 @default.
• W2022251390 cites W2044869263 @default.
• W2022251390 cites W2048096515 @default.
• W2022251390 cites W2058607011 @default.
• W2022251390 cites W2060725813 @default.
• W2022251390 cites W2071940088 @default.
• W2022251390 cites W2095032529 @default.
• W2022251390 cites W2097183016 @default.
• W2022251390 cites W2112311127 @default.
• W2022251390 cites W2121625674 @default.
• W2022251390 cites W2140611255 @default.
• W2022251390 cites W2146330193 @default.
• W2022251390 cites W2149626794 @default.
• W2022251390 cites W2154332957 @default.
• W2022251390 cites W2241278470 @default.
• W2022251390 cites W255872526 @default.
• W2022251390 doi "https://doi.org/10.1007/s11307-013-0653-8" @default.
• W2022251390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3800697" @default.
• W2022251390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23733229" @default.
• W2022251390 hasPublicationYear "2013" @default.
• W2022251390 type Work @default.
• W2022251390 sameAs 2022251390 @default.
• W2022251390 citedByCount "1" @default.
• W2022251390 countsByYear W20222513902021 @default.
• W2022251390 crossrefType "journal-article" @default.
• W2022251390 hasAuthorship W2022251390A5017592912 @default.
• W2022251390 hasAuthorship W2022251390A5035945225 @default.
• W2022251390 hasAuthorship W2022251390A5042088122 @default.
• W2022251390 hasBestOaLocation W20222513902 @default.
• W2022251390 hasConcept C121332964 @default.
• W2022251390 hasConcept C134306372 @default.
• W2022251390 hasConcept C150903083 @default.
• W2022251390 hasConcept C153911025 @default.
• W2022251390 hasConcept C159654299 @default.
• W2022251390 hasConcept C181199279 @default.
• W2022251390 hasConcept C185592680 @default.
• W2022251390 hasConcept C197336794 @default.
• W2022251390 hasConcept C203014093 @default.
• W2022251390 hasConcept C207001950 @default.
• W2022251390 hasConcept C2777676563 @default.
• W2022251390 hasConcept C29331040 @default.
• W2022251390 hasConcept C33923547 @default.
• W2022251390 hasConcept C40209533 @default.
• W2022251390 hasConcept C46141821 @default.
• W2022251390 hasConcept C502942594 @default.
• W2022251390 hasConcept C542903549 @default.
• W2022251390 hasConcept C55493867 @default.
• W2022251390 hasConcept C71924100 @default.
• W2022251390 hasConcept C86803240 @default.
• W2022251390 hasConceptScore W2022251390C121332964 @default.
• W2022251390 hasConceptScore W2022251390C134306372 @default.
• W2022251390 hasConceptScore W2022251390C150903083 @default.
• W2022251390 hasConceptScore W2022251390C153911025 @default.
• W2022251390 hasConceptScore W2022251390C159654299 @default.
• W2022251390 hasConceptScore W2022251390C181199279 @default.
• W2022251390 hasConceptScore W2022251390C185592680 @default.
• W2022251390 hasConceptScore W2022251390C197336794 @default.
• W2022251390 hasConceptScore W2022251390C203014093 @default.
• W2022251390 hasConceptScore W2022251390C207001950 @default.
• W2022251390 hasConceptScore W2022251390C2777676563 @default.
• W2022251390 hasConceptScore W2022251390C29331040 @default.
• W2022251390 hasConceptScore W2022251390C33923547 @default.
• W2022251390 hasConceptScore W2022251390C40209533 @default.
• W2022251390 hasConceptScore W2022251390C46141821 @default.
• W2022251390 hasConceptScore W2022251390C502942594 @default.
• W2022251390 hasConceptScore W2022251390C542903549 @default.
• W2022251390 hasConceptScore W2022251390C55493867 @default.
• W2022251390 hasConceptScore W2022251390C71924100 @default.
• W2022251390 hasConceptScore W2022251390C86803240 @default.
• W2022251390 hasIssue "6" @default.
• W2022251390 hasLocation W20222513901 @default.
• W2022251390 hasLocation W20222513902 @default.
• W2022251390 hasLocation W20222513903 @default.
• W2022251390 hasLocation W20222513904 @default.
• W2022251390 hasOpenAccess W2022251390 @default.
• W2022251390 hasPrimaryLocation W20222513901 @default.
• W2022251390 hasRelatedWork W1566089468 @default.
• W2022251390 hasRelatedWork W1981840671 @default.
• W2022251390 hasRelatedWork W1999833851 @default.
• W2022251390 hasRelatedWork W2001114257 @default.
• W2022251390 hasRelatedWork W2183733678 @default.

• next