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• W2022252561 endingPage "18023" @default.
• W2022252561 startingPage "18018" @default.
• W2022252561 abstract "According to the cisternal maturation hypothesis, endoplasmic reticulum (ER)-derived membranes nucleate new Golgi cisternae. The yeast Saccharomyces cerevisiae offers a unique opportunity to test this idea because small buds contain both ER and Golgi structures early in the cell cycle. We previously predicted that mutants defective in ER inheritance also would show defects in Golgi inheritance. Surprisingly, studies of S. cerevisiae have not revealed the expected link between ER and Golgi inheritance. Here, we revisit this issue by generating mutant strains in which many of the small buds are devoid of detectable ER. These strains also show defects in the inheritance of both early and late Golgi cisternae. Strikingly, virtually all of the buds that lack ER also lack early Golgi cisternae. Our results fit with the idea that membranes exported from the ER coalesce with vesicles derived from existing Golgi compartments to generate new Golgi cisternae. This basic mechanism of Golgi inheritance may be conserved from yeast to vertebrate cells." @default.
• W2022252561 created "2016-06-24" @default.
• W2022252561 creator A5006514294 @default.
• W2022252561 creator A5047963204 @default.
• W2022252561 creator A5053922054 @default.
• W2022252561 date "2004-12-13" @default.
• W2022252561 modified "2023-09-26" @default.
• W2022252561 title "Golgi inheritance in small buds of <i>Saccharomyces cerevisiae</i> is linked to endoplasmic reticulum inheritance" @default.
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• W2022252561 doi "https://doi.org/10.1073/pnas.0408256102" @default.
• W2022252561 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/539800" @default.
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• W2022252561 hasPublicationYear "2004" @default.
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