Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022253114> ?p ?o ?g. }
- W2022253114 endingPage "116" @default.
- W2022253114 startingPage "107" @default.
- W2022253114 abstract "Metabolites derived from superoxide (O2.-) and nitric oxide (NO.) play an important role in antimicrobial and antitumoral defense, but may also harm the host. Low levels of such metabolites can also facilitate viral replication because of their mitogenic effects on cells. Most viruses grow better in proliferating cells, and indeed, many viruses induce in their host cell changes similar to those seen early after treatment with mitogenic lectins. Influenza and paramyxo-viruses activate in phagocytes in the generation of superoxide by a mechanism involving the interaction between the viral surface glycoproteins and the phagocyte's plasma membrane. Interestingly, viruses that activate this host defense mechanism are toxic when injected in the bloodstream of animals. Mice infected with influenza virus undergo oxidative stress. In addition, a wide array of cytokines are formed in the lung, contributing to the systemic effects of influenza. Oxidative stress is seen also in chronic viral infections, such as AIDS and viral hepatitis. Oxidant production in viral hepatitis may contribute to the emergence of hepatocellular carcinoma, a tumor seen in patients after years of chronic inflammation of the liver. Antioxidants and agents that downregulate proinflammatory cytokines and lipid mediators may be a useful complement to specific antiviral drugs in the therapy of viral diseases." @default.
- W2022253114 created "2016-06-24" @default.
- W2022253114 creator A5082260150 @default.
- W2022253114 date "1997-01-01" @default.
- W2022253114 modified "2023-09-26" @default.
- W2022253114 title "Reactive oxygen species and nitric oxide in viral diseases" @default.
- W2022253114 cites W1481096307 @default.
- W2022253114 cites W1508954734 @default.
- W2022253114 cites W1568529372 @default.
- W2022253114 cites W1578640083 @default.
- W2022253114 cites W1582040579 @default.
- W2022253114 cites W1582981629 @default.
- W2022253114 cites W1663957057 @default.
- W2022253114 cites W169111171 @default.
- W2022253114 cites W1845926440 @default.
- W2022253114 cites W1897984827 @default.
- W2022253114 cites W1963614091 @default.
- W2022253114 cites W1966242477 @default.
- W2022253114 cites W1967517010 @default.
- W2022253114 cites W1967637082 @default.
- W2022253114 cites W1973809950 @default.
- W2022253114 cites W1977164798 @default.
- W2022253114 cites W1983186759 @default.
- W2022253114 cites W1991674134 @default.
- W2022253114 cites W1997001042 @default.
- W2022253114 cites W1999734764 @default.
- W2022253114 cites W2003023303 @default.
- W2022253114 cites W2003299766 @default.
- W2022253114 cites W2005466083 @default.
- W2022253114 cites W2007925188 @default.
- W2022253114 cites W2012609779 @default.
- W2022253114 cites W2021290089 @default.
- W2022253114 cites W2022003414 @default.
- W2022253114 cites W2023120361 @default.
- W2022253114 cites W2023213697 @default.
- W2022253114 cites W2023518603 @default.
- W2022253114 cites W2026995847 @default.
- W2022253114 cites W2029054651 @default.
- W2022253114 cites W2037049937 @default.
- W2022253114 cites W2038533958 @default.
- W2022253114 cites W2039409172 @default.
- W2022253114 cites W2055111778 @default.
- W2022253114 cites W2055509000 @default.
- W2022253114 cites W2058461613 @default.
- W2022253114 cites W2062919890 @default.
- W2022253114 cites W2065152876 @default.
- W2022253114 cites W2067632405 @default.
- W2022253114 cites W2068797155 @default.
- W2022253114 cites W2071407275 @default.
- W2022253114 cites W2073825052 @default.
- W2022253114 cites W2076266437 @default.
- W2022253114 cites W2078898097 @default.
- W2022253114 cites W2085342904 @default.
- W2022253114 cites W2089270789 @default.
- W2022253114 cites W2089421056 @default.
- W2022253114 cites W2094050302 @default.
- W2022253114 cites W2097322191 @default.
- W2022253114 cites W2099644089 @default.
- W2022253114 cites W2109825003 @default.
- W2022253114 cites W2146354739 @default.
- W2022253114 cites W2152611825 @default.
- W2022253114 cites W2162300777 @default.
- W2022253114 cites W2179702494 @default.
- W2022253114 cites W2243420484 @default.
- W2022253114 cites W2287126786 @default.
- W2022253114 cites W2315915946 @default.
- W2022253114 cites W2338797763 @default.
- W2022253114 cites W2401416851 @default.
- W2022253114 cites W2410444728 @default.
- W2022253114 cites W4234554022 @default.
- W2022253114 doi "https://doi.org/10.1007/bf02778986" @default.
- W2022253114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9152514" @default.
- W2022253114 hasPublicationYear "1997" @default.
- W2022253114 type Work @default.
- W2022253114 sameAs 2022253114 @default.
- W2022253114 citedByCount "112" @default.
- W2022253114 countsByYear W20222531142012 @default.
- W2022253114 countsByYear W20222531142013 @default.
- W2022253114 countsByYear W20222531142014 @default.
- W2022253114 countsByYear W20222531142015 @default.
- W2022253114 countsByYear W20222531142016 @default.
- W2022253114 countsByYear W20222531142017 @default.
- W2022253114 countsByYear W20222531142018 @default.
- W2022253114 countsByYear W20222531142019 @default.
- W2022253114 countsByYear W20222531142020 @default.
- W2022253114 countsByYear W20222531142021 @default.
- W2022253114 countsByYear W20222531142022 @default.
- W2022253114 countsByYear W20222531142023 @default.
- W2022253114 crossrefType "journal-article" @default.
- W2022253114 hasAuthorship W2022253114A5082260150 @default.
- W2022253114 hasBestOaLocation W20222531142 @default.
- W2022253114 hasConcept C134018914 @default.
- W2022253114 hasConcept C140704245 @default.
- W2022253114 hasConcept C159047783 @default.
- W2022253114 hasConcept C164027704 @default.
- W2022253114 hasConcept C181199279 @default.
- W2022253114 hasConcept C203014093 @default.
- W2022253114 hasConcept C2522874641 @default.