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- W2022255282 abstract "Primary objective: The present study used fMRI (functional magnetic resonance imaging) to objectively assess cognitive fatigue in persons with traumatic brain injury (TBI). It was hypothesized that while performing a cognitive task, TBI participants would show increased brain activity over time, indicative of increased cerebral ‘effort’ which might manifest as the subjective feeling of cognitive fatigue.Methods and procedures: Functional MRI was used to track brain activity across time while 11 TBI patients with moderate–severe injury and 11 age-matched healthy controls (HCs) performed a modified Symbol Digit Modalities Task (mSDMT). Cognitive fatigue was operationally defined as a relative increase in cerebral activation across time compared to that seen in HCs. ROIs were derived from the Chauduri and Behan model of cognitive fatigue.Main outcomes and results: While performing the mSDMT, participants with a TBI showed increased activity, while HCs subsequently showed decreased activity in several regions including the middle frontal gyrus, superior parietal cortex, basal ganglia and anterior cingulate.Conclusions: Increased brain activity exhibited by participants with a TBI might represent increased cerebral effort which may be manifested as cognitive fatigue. Functional MRI appears to be a potentially useful tool for understanding the neural mechanisms associated with cognitive fatigue in TBI." @default.
- W2022255282 created "2016-06-24" @default.
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- W2022255282 date "2009-01-01" @default.
- W2022255282 modified "2023-10-01" @default.
- W2022255282 title "The neural correlates of cognitive fatigue in traumatic brain injury using functional MRI" @default.
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- W2022255282 doi "https://doi.org/10.1080/02699050902788519" @default.
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