Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022255311> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2022255311 endingPage "307" @default.
- W2022255311 startingPage "289" @default.
- W2022255311 abstract "Recognition of protein-DNA binding sites in genomic sequences is a crucial step for discovering biological functions of genomic sequences. Explosive growth in availability of sequence information has resulted in a demand for binding site detection methods with high specificity. The motivation of the work presented here is to address this demand by a systematic approach based on Maximum Likelihood Estimation. A general framework is developed in which a large class of binding site detection methods can be described in a uniform and consistent way. Protein-DNA binding is determined by binding energy, which is an approximately linear function within the space of sequence words. All matrix based binding word detectors can be regarded as different linear classifiers which attempt to estimate the linear separation implied by the binding energy function. The standard approaches of consensus sequences and profile matrices are described using this framework. A maximum likelihood approach for determining this linear separation leads to a novel matrix type, called the binding matrix. The binding matrix is the most specific matrix based classifier which is consistent with the input set of known binding words. It achieves significant improvements in specificity compared to other matrices. This is demonstrated using 95 sets of experimentally determined binding words provided by the TRANSFAC database." @default.
- W2022255311 created "2016-06-24" @default.
- W2022255311 creator A5014856404 @default.
- W2022255311 creator A5068369157 @default.
- W2022255311 creator A5074101757 @default.
- W2022255311 date "2004-06-01" @default.
- W2022255311 modified "2023-09-25" @default.
- W2022255311 title "BINDING MATRIX: A NOVEL APPROACH FOR BINDING SITE RECOGNITION" @default.
- W2022255311 cites W1498410508 @default.
- W2022255311 cites W1552703317 @default.
- W2022255311 cites W1562374859 @default.
- W2022255311 cites W1983405741 @default.
- W2022255311 cites W1988303029 @default.
- W2022255311 cites W1998300401 @default.
- W2022255311 cites W2018507982 @default.
- W2022255311 cites W2031121939 @default.
- W2022255311 cites W2032548898 @default.
- W2022255311 cites W2035564383 @default.
- W2022255311 cites W2057000344 @default.
- W2022255311 cites W2066562848 @default.
- W2022255311 cites W2069426496 @default.
- W2022255311 cites W2074703985 @default.
- W2022255311 cites W2108190672 @default.
- W2022255311 cites W2142890842 @default.
- W2022255311 cites W2146393977 @default.
- W2022255311 cites W2149769193 @default.
- W2022255311 cites W2154100003 @default.
- W2022255311 cites W2158089930 @default.
- W2022255311 cites W2166277117 @default.
- W2022255311 doi "https://doi.org/10.1142/s0219720004000569" @default.
- W2022255311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15297983" @default.
- W2022255311 hasPublicationYear "2004" @default.
- W2022255311 type Work @default.
- W2022255311 sameAs 2022255311 @default.
- W2022255311 citedByCount "14" @default.
- W2022255311 countsByYear W20222553112012 @default.
- W2022255311 countsByYear W20222553112013 @default.
- W2022255311 countsByYear W20222553112014 @default.
- W2022255311 crossrefType "journal-article" @default.
- W2022255311 hasAuthorship W2022255311A5014856404 @default.
- W2022255311 hasAuthorship W2022255311A5068369157 @default.
- W2022255311 hasAuthorship W2022255311A5074101757 @default.
- W2022255311 hasConcept C101762097 @default.
- W2022255311 hasConcept C104317684 @default.
- W2022255311 hasConcept C106487976 @default.
- W2022255311 hasConcept C107824862 @default.
- W2022255311 hasConcept C11413529 @default.
- W2022255311 hasConcept C14036430 @default.
- W2022255311 hasConcept C150194340 @default.
- W2022255311 hasConcept C153180895 @default.
- W2022255311 hasConcept C154945302 @default.
- W2022255311 hasConcept C185592680 @default.
- W2022255311 hasConcept C2778112365 @default.
- W2022255311 hasConcept C33923547 @default.
- W2022255311 hasConcept C3662595 @default.
- W2022255311 hasConcept C41008148 @default.
- W2022255311 hasConcept C43617362 @default.
- W2022255311 hasConcept C54355233 @default.
- W2022255311 hasConcept C70721500 @default.
- W2022255311 hasConcept C86803240 @default.
- W2022255311 hasConceptScore W2022255311C101762097 @default.
- W2022255311 hasConceptScore W2022255311C104317684 @default.
- W2022255311 hasConceptScore W2022255311C106487976 @default.
- W2022255311 hasConceptScore W2022255311C107824862 @default.
- W2022255311 hasConceptScore W2022255311C11413529 @default.
- W2022255311 hasConceptScore W2022255311C14036430 @default.
- W2022255311 hasConceptScore W2022255311C150194340 @default.
- W2022255311 hasConceptScore W2022255311C153180895 @default.
- W2022255311 hasConceptScore W2022255311C154945302 @default.
- W2022255311 hasConceptScore W2022255311C185592680 @default.
- W2022255311 hasConceptScore W2022255311C2778112365 @default.
- W2022255311 hasConceptScore W2022255311C33923547 @default.
- W2022255311 hasConceptScore W2022255311C3662595 @default.
- W2022255311 hasConceptScore W2022255311C41008148 @default.
- W2022255311 hasConceptScore W2022255311C43617362 @default.
- W2022255311 hasConceptScore W2022255311C54355233 @default.
- W2022255311 hasConceptScore W2022255311C70721500 @default.
- W2022255311 hasConceptScore W2022255311C86803240 @default.
- W2022255311 hasIssue "02" @default.
- W2022255311 hasLocation W20222553111 @default.
- W2022255311 hasLocation W20222553112 @default.
- W2022255311 hasOpenAccess W2022255311 @default.
- W2022255311 hasPrimaryLocation W20222553111 @default.
- W2022255311 hasRelatedWork W2037787140 @default.
- W2022255311 hasRelatedWork W2039286232 @default.
- W2022255311 hasRelatedWork W2104330120 @default.
- W2022255311 hasRelatedWork W2132688829 @default.
- W2022255311 hasRelatedWork W2138717237 @default.
- W2022255311 hasRelatedWork W2162836426 @default.
- W2022255311 hasRelatedWork W2299149677 @default.
- W2022255311 hasRelatedWork W2350709984 @default.
- W2022255311 hasRelatedWork W311334411 @default.
- W2022255311 hasRelatedWork W2460184855 @default.
- W2022255311 hasVolume "02" @default.
- W2022255311 isParatext "false" @default.
- W2022255311 isRetracted "false" @default.
- W2022255311 magId "2022255311" @default.
- W2022255311 workType "article" @default.