FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022255991> ?p ?o ?g. }

• W2022255991 endingPage "216" @default.
• W2022255991 startingPage "211" @default.
• W2022255991 abstract "Myoglobin is presumably the most studied protein in biology. Its functional properties as a dioxygen storage and facilitator of dioxygen transport are widely acknowledged. Experimental evidence also implicates an essential role for myoglobin in the heart in regulating nitric oxide homeostasis. Under normoxia, oxygenated myoglobin can scavenge excessive nitric oxide, while under hypoxia, deoxygenated myoglobin can reduce nitrite, an oxidative product of nitric oxide, to bioactive nitric oxide. Myoglobin-driven nitrite reduction can protect the heart from ischemia and reperfusion injury. While horse and mouse myoglobin have been previously described to reduce nitrite under these conditions, a comparable activity has not been detected in human myoglobin. We here show that human myoglobin is a fully functional nitrite reductase. To study the role of human myoglobin for nitric oxide homeostasis we used repeated photometric wavelength scans and chemiluminescence based experiments. The results revealed that oxygenated human myoglobin reacts with nitrite-derived nitric oxide to form ferric myoglobin and that deoxygenated human myoglobin acts as a nitrite reductase in vitro and in situ. Rates of both nitric oxide scavenging and nitrite reduction were significantly higher in human compared to horse myoglobin. These data extend the existing knowledge about the functional properties of human myoglobin and are the basis for further translational studies towards the importance of myoglobin for nitric oxide metabolism in humans." @default.
• W2022255991 created "2016-06-24" @default.
• W2022255991 creator A5010019842 @default.
• W2022255991 creator A5027444894 @default.
• W2022255991 creator A5061494282 @default.
• W2022255991 creator A5067753312 @default.
• W2022255991 creator A5071924250 @default.
• W2022255991 creator A5084655624 @default.
• W2022255991 creator A5087518489 @default.
• W2022255991 creator A5091291935 @default.
• W2022255991 date "2012-05-01" @default.
• W2022255991 modified "2023-09-26" @default.
• W2022255991 title "Assessment of the functional diversity of human myoglobin" @default.
• W2022255991 cites W1662116282 @default.
• W2022255991 cites W1947047050 @default.
• W2022255991 cites W1966726553 @default.
• W2022255991 cites W1968488846 @default.
• W2022255991 cites W1969847771 @default.
• W2022255991 cites W1972443719 @default.
• W2022255991 cites W1974821362 @default.
• W2022255991 cites W1984396722 @default.
• W2022255991 cites W1990594604 @default.
• W2022255991 cites W1990710075 @default.
• W2022255991 cites W1992391313 @default.
• W2022255991 cites W2004691285 @default.
• W2022255991 cites W2005466083 @default.
• W2022255991 cites W2017907872 @default.
• W2022255991 cites W2020937749 @default.
• W2022255991 cites W2033357754 @default.
• W2022255991 cites W2035571047 @default.
• W2022255991 cites W2037967237 @default.
• W2022255991 cites W2043355876 @default.
• W2022255991 cites W2046628294 @default.
• W2022255991 cites W2048408379 @default.
• W2022255991 cites W2068395093 @default.
• W2022255991 cites W2071560742 @default.
• W2022255991 cites W2094188595 @default.
• W2022255991 cites W2094949453 @default.
• W2022255991 cites W2096118264 @default.
• W2022255991 cites W2098453482 @default.
• W2022255991 cites W2098624101 @default.
• W2022255991 cites W2104194825 @default.
• W2022255991 cites W2105104689 @default.
• W2022255991 cites W2111609140 @default.
• W2022255991 cites W2119493536 @default.
• W2022255991 cites W2119523564 @default.
• W2022255991 cites W2126549678 @default.
• W2022255991 cites W2136280068 @default.
• W2022255991 cites W2137051692 @default.
• W2022255991 cites W2150393833 @default.
• W2022255991 cites W2151056944 @default.
• W2022255991 cites W2152676202 @default.
• W2022255991 cites W2174125995 @default.
• W2022255991 cites W2175985062 @default.
• W2022255991 cites W2313326603 @default.
• W2022255991 doi "https://doi.org/10.1016/j.niox.2012.03.001" @default.
• W2022255991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22425779" @default.
• W2022255991 hasPublicationYear "2012" @default.
• W2022255991 type Work @default.
• W2022255991 sameAs 2022255991 @default.
• W2022255991 citedByCount "32" @default.
• W2022255991 countsByYear W20222559912012 @default.
• W2022255991 countsByYear W20222559912013 @default.
• W2022255991 countsByYear W20222559912014 @default.
• W2022255991 countsByYear W20222559912015 @default.
• W2022255991 countsByYear W20222559912016 @default.
• W2022255991 countsByYear W20222559912017 @default.
• W2022255991 countsByYear W20222559912018 @default.
• W2022255991 countsByYear W20222559912019 @default.
• W2022255991 countsByYear W20222559912020 @default.
• W2022255991 countsByYear W20222559912021 @default.
• W2022255991 countsByYear W20222559912022 @default.
• W2022255991 crossrefType "journal-article" @default.
• W2022255991 hasAuthorship W2022255991A5010019842 @default.
• W2022255991 hasAuthorship W2022255991A5027444894 @default.
• W2022255991 hasAuthorship W2022255991A5061494282 @default.
• W2022255991 hasAuthorship W2022255991A5067753312 @default.
• W2022255991 hasAuthorship W2022255991A5071924250 @default.
• W2022255991 hasAuthorship W2022255991A5084655624 @default.
• W2022255991 hasAuthorship W2022255991A5087518489 @default.
• W2022255991 hasAuthorship W2022255991A5091291935 @default.
• W2022255991 hasConcept C178790620 @default.
• W2022255991 hasConcept C181199279 @default.
• W2022255991 hasConcept C185592680 @default.
• W2022255991 hasConcept C20705724 @default.
• W2022255991 hasConcept C2776179834 @default.
• W2022255991 hasConcept C2776217839 @default.
• W2022255991 hasConcept C2776384668 @default.
• W2022255991 hasConcept C2778063876 @default.
• W2022255991 hasConcept C2781341435 @default.
• W2022255991 hasConcept C519581460 @default.
• W2022255991 hasConcept C55493867 @default.
• W2022255991 hasConceptScore W2022255991C178790620 @default.
• W2022255991 hasConceptScore W2022255991C181199279 @default.
• W2022255991 hasConceptScore W2022255991C185592680 @default.
• W2022255991 hasConceptScore W2022255991C20705724 @default.
• W2022255991 hasConceptScore W2022255991C2776179834 @default.
• W2022255991 hasConceptScore W2022255991C2776217839 @default.

• next