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• W2022256380 abstract "The commencement of the “-omic” evolution essentially followed the successful completion of the human genome project in 2003. Genomics, proteomics, transcriptomics, metabolomics and pharmacogenomics are only a few of the “-omics”; they deal with, respectively, the study and understanding of the genome, proteins, all RNA molecules, metabolites and the therapeutic response of drugs according to genomic variations. Elucidation of the function of the entire human genome is the Holy Grail of medicine and would provide information that is unique to each individual and could be used for predicting risk of developing disease, for administering appropriate therapeutic interventions, for developmental patterns, for aging and for many other life functions. Attempts have been made to define a model of health care that could use this concept and benefit patients. Personalized or individualized medicine is an emerging field within health care that uses an individual’s genomic information and its resulting products—RNA, proteins and metabolites—to customize care that is specific to that individual. The goals of personalized medicine are to determine a person’s susceptibility or risk of developing disease, establishing a diagnosis, determining disease patterns and prognosis, determining appropriate interventions, predicting and monitoring therapeutic response, and predicting an individual’s response to environmental and microbial challenges. Two recent reports exemplify the potential of personalized medicine. Investigators in one study identified a set of 34 genes that could distinguish individuals with transient ischemic attacks (TIAs) from a control group and do so with 100 percent sensitivity and specificity. Notably, these particular genes also have been linked to prothrombin and platelet activation and to systemic inflammation, which could explain the pathogenesis of TIA. In another study, investigators successfully transferred the factor IX (FIX) gene to people with hemophilia B, resulting in enough FIX production to cease prophylactic FIX therapy. Until recently, the sequencing of an entire exome—the proteincoding regions of the genome—has been very expensive. However, with next-generation DNA sequencing, the ability to, among many other things, target mRNA and methylated regions of DNA in a single cell provides better and faster microarray-based singlenucleotide polymorphism detection. Also, the cost of doing so has dropped below $1,000. The human genome has provided us with an immense database, but it is not yet clear how this information relates to health, disease and quality of life. EDITORIAL" @default.
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• W2022256380 date "2012-02-01" @default.
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• W2022256380 title "Personalized oral health care" @default.
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• W2022256380 doi "https://doi.org/10.14219/jada.archive.2012.0103" @default.
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