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• W2022256479 startingPage "1473" @default.
• W2022256479 abstract "Dendritic amine and guanidinium group-modified nanoparticles were investigated for the delivery of model peptide drug into primary osteoclast precursor cells (bone marrow macrophages; BMMs). The model peptide drug was encapsulated into the nanoparticle by dropping the drug/carrier dissolved in dimethylsulfoxide/methylene chloride cosolvent into water containing poly(vinyl alcohol) as a stabilizer. Flow cytometry and spectrofluorimetry analysis indicated that the model drug itself was not taken up by the BMMs; however, nanoparticle systems underwent significant cellular uptake. In particular, guanidinium group-modified nanoparticles were taken up more efficiently than amine group-modified ones. Cell viability studies showed that both amine and guanidinium group-modified nanoparticles exhibited no significant cytotoxicity up to 100 μg/mL against the cells." @default.
• W2022256479 created "2016-06-24" @default.
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• W2022256479 date "2010-07-19" @default.
• W2022256479 modified "2023-09-23" @default.
• W2022256479 title "Oligopeptide Delivery Carrier for Osteoclast Precursors" @default.
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• W2022256479 doi "https://doi.org/10.1021/bc100066k" @default.
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• W2022256479 hasPublicationYear "2010" @default.
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