FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022257153> ?p ?o ?g. }

• W2022257153 endingPage "411" @default.
• W2022257153 startingPage "401" @default.
• W2022257153 abstract "Abstract The glial scar resulting from spinal cord injury is rich in chondroitin sulfate proteoglycan (CSPG), a formidable barrier to axonal regeneration. We explored the possibility of breaching that barrier by first examining the scar in a functional in vitro model. We found that embryonic stem cell-derived neural lineage cells (ESNLCs) with prominent expression of nerve glial antigen 2 (NG2) survived, passed through an increasingly inhibitory gradient of CSPG, and expressed matrix metalloproteinase 9 (MMP-9) at the appropriate stage of their development. Outgrowth of axons from ESNLCs followed because the migrating cells sculpted pathways in which CSPG was degraded. The degradative mechanism involved MMP-9 but not MMP-2. To confirm these results in vivo, we transplanted ESNLCs directly into the cavity of a contused spinal cord 9 days after injury. A week later, ESNLCs survived and were expressing both NG2 and MMP-9. Their axons had grown through long distances (&gt;10 mm), although they preferred to traverse white rather than gray matter. These data are consistent with the concept that expression of inhibitory CSPG within the injury scar is an important impediment to regeneration but that NG2+ progenitors derived from ESNLCs can modify the microenvironment to allow axons to grow through the barrier. This beneficial action may be partly due to developmental expression of MMP-9. We conclude that it might eventually be possible to encourage axonal regeneration in the human spinal cord by transplanting ESNLCs or other cells that express NG2." @default.
• W2022257153 created "2016-06-24" @default.
• W2022257153 creator A5001997941 @default.
• W2022257153 creator A5018907952 @default.
• W2022257153 creator A5027007843 @default.
• W2022257153 creator A5034071001 @default.
• W2022257153 creator A5036622608 @default.
• W2022257153 creator A5045430644 @default.
• W2022257153 creator A5066887020 @default.
• W2022257153 creator A5080622751 @default.
• W2022257153 date "2015-02-23" @default.
• W2022257153 modified "2023-10-13" @default.
• W2022257153 title "NG2+ Progenitors Derived From Embryonic Stem Cells Penetrate Glial Scar and Promote Axonal Outgrowth Into White Matter After Spinal Cord Injury" @default.
• W2022257153 cites W1516174218 @default.
• W2022257153 cites W1523799993 @default.
• W2022257153 cites W1574222606 @default.
• W2022257153 cites W1586855301 @default.
• W2022257153 cites W1621337337 @default.
• W2022257153 cites W1676877312 @default.
• W2022257153 cites W1817027815 @default.
• W2022257153 cites W1822650859 @default.
• W2022257153 cites W1824808675 @default.
• W2022257153 cites W1846608835 @default.
• W2022257153 cites W1908112684 @default.
• W2022257153 cites W1952053031 @default.
• W2022257153 cites W1974432822 @default.
• W2022257153 cites W1980162719 @default.
• W2022257153 cites W1981621010 @default.
• W2022257153 cites W1994049385 @default.
• W2022257153 cites W1994257911 @default.
• W2022257153 cites W2006135298 @default.
• W2022257153 cites W2006494979 @default.
• W2022257153 cites W2011353038 @default.
• W2022257153 cites W2012928251 @default.
• W2022257153 cites W2021494076 @default.
• W2022257153 cites W2023849839 @default.
• W2022257153 cites W2025171322 @default.
• W2022257153 cites W2030927825 @default.
• W2022257153 cites W2034597638 @default.
• W2022257153 cites W2036498908 @default.
• W2022257153 cites W2038226174 @default.
• W2022257153 cites W2039608234 @default.
• W2022257153 cites W2040022455 @default.
• W2022257153 cites W2047724409 @default.
• W2022257153 cites W2059372622 @default.
• W2022257153 cites W2060111610 @default.
• W2022257153 cites W2061558355 @default.
• W2022257153 cites W2063877300 @default.
• W2022257153 cites W2064423627 @default.
• W2022257153 cites W2073103657 @default.
• W2022257153 cites W2075741564 @default.
• W2022257153 cites W2078486462 @default.
• W2022257153 cites W2080070415 @default.
• W2022257153 cites W2081489490 @default.
• W2022257153 cites W2084086889 @default.
• W2022257153 cites W2085801023 @default.
• W2022257153 cites W2085935458 @default.
• W2022257153 cites W2090389580 @default.
• W2022257153 cites W2092262146 @default.
• W2022257153 cites W2092823526 @default.
• W2022257153 cites W2093026922 @default.
• W2022257153 cites W2096988407 @default.
• W2022257153 cites W2097871563 @default.
• W2022257153 cites W2100976322 @default.
• W2022257153 cites W2104907082 @default.
• W2022257153 cites W2107589629 @default.
• W2022257153 cites W2116058299 @default.
• W2022257153 cites W2118427313 @default.
• W2022257153 cites W2119318470 @default.
• W2022257153 cites W2125937448 @default.
• W2022257153 cites W2127447774 @default.
• W2022257153 cites W2135315011 @default.
• W2022257153 cites W2138576698 @default.
• W2022257153 cites W2139137961 @default.
• W2022257153 cites W2143936339 @default.
• W2022257153 cites W2149286305 @default.
• W2022257153 cites W2151241124 @default.
• W2022257153 cites W2157338102 @default.
• W2022257153 cites W2164406367 @default.
• W2022257153 cites W2338446007 @default.
• W2022257153 cites W4243180063 @default.
• W2022257153 cites W939316860 @default.
• W2022257153 doi "https://doi.org/10.5966/sctm.2014-0107" @default.
• W2022257153 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4367502" @default.
• W2022257153 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25713464" @default.
• W2022257153 hasPublicationYear "2015" @default.
• W2022257153 type Work @default.
• W2022257153 sameAs 2022257153 @default.
• W2022257153 citedByCount "36" @default.
• W2022257153 countsByYear W20222571532015 @default.
• W2022257153 countsByYear W20222571532016 @default.
• W2022257153 countsByYear W20222571532017 @default.
• W2022257153 countsByYear W20222571532018 @default.
• W2022257153 countsByYear W20222571532019 @default.
• W2022257153 countsByYear W20222571532020 @default.
• W2022257153 countsByYear W20222571532021 @default.
• W2022257153 countsByYear W20222571532022 @default.
• W2022257153 countsByYear W20222571532023 @default.

• next