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• W2022258697 abstract "Vasoactive intestinal peptide (VIP), a major neurotransmitter of peripheral nerves, has been suggested to function in host defense by regulating local human immune function. Indirect evidence has been marshaled that VIP can function as a switch factor for IgA in human Ig isotype recombination. In this study we directly tested the ability of VIP to function as a factor driving human B cells into IgA producing cells by assessing its ability to induce switch circular DNA representing direct mu to alpha switching. In addition we determined the generation of alpha germ-line transcripts and measured the level of IgA protein produced. Stimulation with VIP and CD40 mAb induced IgA production by human IgD+ B cells while VIP or CD40 alone failed to do so. Stimulation of purified IgD+ B cells with VIP plus CD40 mAb induced generation of switch circular DNA representing in vitro driven isotype switching from mu to alpha. CD40 mAb alone induced alpha germ-line transcripts but not IgA switch circles. Thus VIP, a neurogenic factor, can induce alpha-specific switching in CD40-activated human B cells and may thereby play an important role in directing the humoral immune response at mucosal surfaces." @default.
• W2022258697 created "2016-06-24" @default.
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• W2022258697 date "1996-10-01" @default.
• W2022258697 modified "2023-10-18" @default.
• W2022258697 title "Vasoactive intestinal peptide induces S(alpha)/S(mu) switch circular DNA in human B cells." @default.
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• W2022258697 doi "https://doi.org/10.1172/jci118944" @default.
• W2022258697 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/507583" @default.
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