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- W2022261648 abstract "The cornea, one of the most highly innervated tissues of the body, is innervated by trigeminal sensory afferents. During development, axons are initially repelled at the corneal margin, resulting in the formation of a circumferential nerve ring. The nature and source of guidance molecules that regulate this process remain a mystery. Here, we show that the lens, which immediately underlies the cornea, repels trigeminal axons in vivo and in vitro. Lens ablation results in premature, disorganized corneal innervation and disruption of the nerve ring and ventral plexus. We show that Semaphorin3A (Sema3A) is expressed in the lens epithelium and its receptor Neuropilin-1 (Npn1) is expressed in the trigeminal ganglion during cornea development. Inhibition of Sema3A signaling abrogates axon repulsion by the lens and cornea in vitro and phenocopies lens removal in vivo. These results demonstrate that lens-derived Sema3A mediates initial repulsion of trigeminal sensory axons from the cornea and is necessary for the proper formation of the nerve ring and positioning of the ventral plexus in the choroid fissure." @default.
- W2022261648 created "2016-06-24" @default.
- W2022261648 creator A5019521298 @default.
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- W2022261648 date "2007-06-01" @default.
- W2022261648 modified "2023-10-01" @default.
- W2022261648 title "Lens-derived Semaphorin3A regulates sensory innervation of the cornea" @default.
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- W2022261648 doi "https://doi.org/10.1016/j.ydbio.2007.04.012" @default.
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