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• W2022261795 abstract "Serpulina (Treponema) hyodysenteriae, an anaerobic beta hemolytic spirochaete, is the etiologic agent of swine dysentery. Not much is known at present about the virulence factors of S. hyodysenteriae. However, the hemolysin production of this bacterium is generally accepted to be a virulence factor. To study the exact role of hemolysin production in the pathogenesis of swine dysentery, the gene encoding a hemolysin, tly, was cloned and its nucleotide sequence determined. After inactivation of this gene, the virulence of a tly-minus mutant in mice was tested. The mutant had reduced hemolysis indicating that the tlyencoded hemolysin was not the only hemolysin produced by S. hyodysenteriae. Mice infected with the tly-minus mutant had fewer cecal lesions than mice infected with the wildtype S. hyodysenteriae. It was concluded that the tly-encodedhemolysin might be an important virulence factor, but not the only one. Since it was demonstrated that spirochaetes can be transformed through electroporation, this has made a genetic approach to elucidate the pathogenesis of spirochaetal infections possible. Serpulina (Treponema) hyodysenteriae, eine anaerobe ß-hämolysierende Spirochäte, ist der ätiologische Erreger der Schweinedysenterie. Die Hämolysinproduktion dieses Bakteriums wird allgemein als Virulenzfaktor angesehen. Urn die genaue Rolle der Hämolysinbildung in der Pathogenese der Schweinedysenterie zu untersuchen, wurde das Gen tly, welches ein Hämolysin kodiert, geklont und seine Nukleosetidsequenz bestimmt. Nach Inaktivierung des Gens wurde die Virulenz der tly--Mutante in der Maus geprüft. Die Mutante weist eine verminderte Hämolyse auf, was anzeigt, daß das tly-kodierte Hämolysin nicht das einzige Hamolysin ist, welches S. hyodysenteriae produziert. Mäuse, die mit der tly- -Mutante infiziert wurden, haben weniger Zökalläsionen als Mäuse, die mit dem Wildtyp von S. hyodysenteriae infiziert wurden. Es läßt sich schlußfolgern, daß das tly-kodierte Hämolysin ein wichtiger, aber nicht der einzige Virulenzfaktor ist. Seit gezeigt werden konnte, daß man Spirochäten durch Elektroporation transformieren kann, macht es dieser genetische Ansatz möglich, die Pathogenese der Spirochateninfektionen zu analysieren." @default.
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• W2022261795 date "1993-04-01" @default.
• W2022261795 modified "2023-09-27" @default.
• W2022261795 title "The Role of Hemolysin(s) in the Pathogenesis of Serpulina hyodysenteriae" @default.
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• W2022261795 doi "https://doi.org/10.1016/s0934-8840(11)80848-0" @default.
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