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- W2022264956 abstract "Glycosylation processes are under high natural selection pressure, presumably because these can modulate resistance to infection. Here, we asked whether inactivation of the UDP-galactose:β-galactoside-α1-3-galactosyltransferase (α1,3GT) gene, which ablated the expression of the Galα1-3Galβ1-4GlcNAc-R (α-gal) glycan and allowed for the production of anti-α-gal antibodies (Abs) in humans, confers protection against Plasmodium spp. infection, the causative agent of malaria and a major driving force in human evolution. We demonstrate that both Plasmodium spp. and the human gut pathobiont E. coli O86:B7 express α-gal and that anti-α-gal Abs are associated with protection against malaria transmission in humans as well as in α1,3GT-deficient mice, which produce protective anti-α-gal Abs when colonized by E. coli O86:B7. Anti-α-gal Abs target Plasmodium sporozoites for complement-mediated cytotoxicity in the skin, immediately after inoculation by Anopheles mosquitoes. Vaccination against α-gal confers sterile protection against malaria in mice, suggesting that a similar approach may reduce malaria transmission in humans.PaperFlickeyJraWQiOiI4ZjUxYWNhY2IzYjhiNjNlNzFlYmIzYWFmYTU5NmZmYyIsImFsZyI6IlJTMjU2In0.eyJzdWIiOiJiNTY4NTRiOWEwMzIyNWVjNWEzMTFiZDRmYTQxMTIwOSIsImtpZCI6IjhmNTFhY2FjYjNiOGI2M2U3MWViYjNhYWZhNTk2ZmZjIiwiZXhwIjoxNjc4NzQ3Nzc5fQ.FFm8bZwzFwf7ajRNPM8XiJYlfsSoyXTz1Ehe5Dnl8ta2OY-zgj6uoklOXV19Mj0ap2M2KrOxZjCELRFF59w5lXx893MAS34swgIlR0zKXUIQIZ4wIDwODquRe4ZiBkjA4xQzH9O1ADIUqm4_koBGYcqsWHcxFFFmkGu8vRx-iMwDhHWr3onX6H2OBvhPIQfR7DWI3kAD1mX-0bUdQdMEsUJ5fIl0frpAq9b0pDEK6lUp_bX-E68kxNuGVYyFW2seS7OjE75JleZyTTzjHIrkEV2AyMBLS0w-REpyXPcHmL9-JwKL2GT8ewKK7Eu7G5UWQ8KVa1yhJQCM3nV5LMqQfg(mp4, (15.01 MB) Download video" @default.
- W2022264956 created "2016-06-24" @default.
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- W2022264956 date "2014-12-01" @default.
- W2022264956 modified "2023-10-17" @default.
- W2022264956 title "Gut Microbiota Elicits a Protective Immune Response against Malaria Transmission" @default.
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- W2022264956 doi "https://doi.org/10.1016/j.cell.2014.10.053" @default.