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- W2022265479 abstract "presented research work, a series of S-substituted derivatives of 5-(3-nitrophenyl)-1,3,4-Oxadiazole-2-thiol was synthesized from 3-nitrobenzoic acid. The synthesis was carried out by converting 3-nitrobenzoic acid correspondingly into ester, hydrazide and 5-(3-nitrophenyl)-1,3,4-Oxadiazole-2-thiol (4). Finally, the S-substituted derivatives (6a-m) were brought about by reacting 5- (3-nitrophenyl)-1,3,4-Oxadiazole-2-thiol with different electrophiles (5a-m) in the presence of NaH and N,N-dimethylformamide. Structure elucidation for all the synthesized compounds was executed by different spectroscopic analysis like IR, 1 H-NMR and EI-MS. All the synthesized derivatives were screened for antibacterial activity. Antibacterial potential was sorted out for four gram-negative bacteria including Shigella sonnei, Escherichia coli, Pseudomonas aeruginosa & Salmonella typhi; and two gram- positive bacteria including Bacillus subtilis & Staphylococcus aureus and found results that most of the compounds exhibit significant activity relative to the standard drugs Ciprofloxacin and Gentamycin." @default.
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- W2022265479 date "2013-06-30" @default.
- W2022265479 modified "2023-10-16" @default.
- W2022265479 title "Synthesis, Characterization and Biological Screening of Various S-substituted Derivatives of 5-(3-Nitrophenyl)-1,3,4-Oxadiazole-2-thiol" @default.
- W2022265479 doi "https://doi.org/10.15228/2013.v03.i02.p03" @default.
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