Matches in SemOpenAlex for { <https://semopenalex.org/work/W2022266275> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2022266275 endingPage "535" @default.
- W2022266275 startingPage "530" @default.
- W2022266275 abstract "Monitoring of CsA blood levels two h post-dose (C2) has shown a higher correlation to drug exposure than monitoring of trough levels (C0) at least in adults, but initial doses and target blood levels of CsA have yet to be established in pediatric transplant patients. The objectives of the study were to describe the pharmacokinetics of CsA administered by NGT in the first days after transplantation and the dose of Sandimmun Neoral required to achieve minimum therapeutic range blood levels. This study included 20 pediatric liver transplant recipients (mean age of 3.2 yr) treated with CsA administered by NGT from day one post-transplant until they were able to ingest oral medication. The study was continued until one yr of post-transplant follow-up. Eight h pharmacokinetic profiles were performed on days one, three, and five post-transplant to determine the minimum dose required to achieve the therapeutic range. All children received an initial dose of 15 mg/kg/day of CsA by NGT. Mean CsA doses administered on days one, three, and five were 16.8, 29.5, and 36.5 mg/kg/day, respectively. Mean C0 levels of 119, 310, and 337 ng/mL and mean C2 levels of 213, 753, and 888 ng/mL were obtained. No correlation was found between C0 and C2 levels and the AUC(0-8 h). Intravenous administration of CsA was required in 55% of patients. The biopsy-confirmed acute rejection rate was 45%, with graft and patient survival rates of 95 and 100%, respectively.Poor absorption of CsA in small children requires a considerable increase in dose. CsA exposure cannot be estimated by single C0 or C2 determinations in the early post-transplant period." @default.
- W2022266275 created "2016-06-24" @default.
- W2022266275 creator A5002357735 @default.
- W2022266275 creator A5002796700 @default.
- W2022266275 creator A5004251889 @default.
- W2022266275 creator A5007535679 @default.
- W2022266275 creator A5011836161 @default.
- W2022266275 creator A5030793598 @default.
- W2022266275 creator A5044332612 @default.
- W2022266275 creator A5054821969 @default.
- W2022266275 creator A5072385013 @default.
- W2022266275 creator A5073711492 @default.
- W2022266275 creator A5075135964 @default.
- W2022266275 creator A5079458676 @default.
- W2022266275 creator A5085962394 @default.
- W2022266275 date "2007-06-16" @default.
- W2022266275 modified "2023-10-10" @default.
- W2022266275 title "Cyclosporine monitoring in the early post-transplant period in pediatric liver transplant recipients" @default.
- W2022266275 cites W1972609760 @default.
- W2022266275 cites W1997796472 @default.
- W2022266275 cites W2015736261 @default.
- W2022266275 cites W2021544053 @default.
- W2022266275 cites W2024438194 @default.
- W2022266275 cites W2028293443 @default.
- W2022266275 cites W2046577459 @default.
- W2022266275 cites W2062119858 @default.
- W2022266275 cites W2071743324 @default.
- W2022266275 cites W2092075764 @default.
- W2022266275 cites W2094287284 @default.
- W2022266275 cites W2151707714 @default.
- W2022266275 cites W4250003400 @default.
- W2022266275 doi "https://doi.org/10.1111/j.1399-3046.2007.00697.x" @default.
- W2022266275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17631022" @default.
- W2022266275 hasPublicationYear "2007" @default.
- W2022266275 type Work @default.
- W2022266275 sameAs 2022266275 @default.
- W2022266275 citedByCount "6" @default.
- W2022266275 countsByYear W20222662752012 @default.
- W2022266275 countsByYear W20222662752013 @default.
- W2022266275 countsByYear W20222662752016 @default.
- W2022266275 crossrefType "journal-article" @default.
- W2022266275 hasAuthorship W2022266275A5002357735 @default.
- W2022266275 hasAuthorship W2022266275A5002796700 @default.
- W2022266275 hasAuthorship W2022266275A5004251889 @default.
- W2022266275 hasAuthorship W2022266275A5007535679 @default.
- W2022266275 hasAuthorship W2022266275A5011836161 @default.
- W2022266275 hasAuthorship W2022266275A5030793598 @default.
- W2022266275 hasAuthorship W2022266275A5044332612 @default.
- W2022266275 hasAuthorship W2022266275A5054821969 @default.
- W2022266275 hasAuthorship W2022266275A5072385013 @default.
- W2022266275 hasAuthorship W2022266275A5073711492 @default.
- W2022266275 hasAuthorship W2022266275A5075135964 @default.
- W2022266275 hasAuthorship W2022266275A5079458676 @default.
- W2022266275 hasAuthorship W2022266275A5085962394 @default.
- W2022266275 hasConcept C112705442 @default.
- W2022266275 hasConcept C126322002 @default.
- W2022266275 hasConcept C141071460 @default.
- W2022266275 hasConcept C2779609443 @default.
- W2022266275 hasConcept C2780272996 @default.
- W2022266275 hasConcept C2909675724 @default.
- W2022266275 hasConcept C2911091166 @default.
- W2022266275 hasConcept C31785415 @default.
- W2022266275 hasConcept C71924100 @default.
- W2022266275 hasConcept C90924648 @default.
- W2022266275 hasConceptScore W2022266275C112705442 @default.
- W2022266275 hasConceptScore W2022266275C126322002 @default.
- W2022266275 hasConceptScore W2022266275C141071460 @default.
- W2022266275 hasConceptScore W2022266275C2779609443 @default.
- W2022266275 hasConceptScore W2022266275C2780272996 @default.
- W2022266275 hasConceptScore W2022266275C2909675724 @default.
- W2022266275 hasConceptScore W2022266275C2911091166 @default.
- W2022266275 hasConceptScore W2022266275C31785415 @default.
- W2022266275 hasConceptScore W2022266275C71924100 @default.
- W2022266275 hasConceptScore W2022266275C90924648 @default.
- W2022266275 hasIssue "5" @default.
- W2022266275 hasLocation W20222662751 @default.
- W2022266275 hasLocation W20222662752 @default.
- W2022266275 hasOpenAccess W2022266275 @default.
- W2022266275 hasPrimaryLocation W20222662751 @default.
- W2022266275 hasRelatedWork W1973773113 @default.
- W2022266275 hasRelatedWork W1978047992 @default.
- W2022266275 hasRelatedWork W2001036958 @default.
- W2022266275 hasRelatedWork W2024252223 @default.
- W2022266275 hasRelatedWork W2045521227 @default.
- W2022266275 hasRelatedWork W2065933810 @default.
- W2022266275 hasRelatedWork W2983691758 @default.
- W2022266275 hasRelatedWork W3160313759 @default.
- W2022266275 hasRelatedWork W4381706042 @default.
- W2022266275 hasRelatedWork W560926806 @default.
- W2022266275 hasVolume "11" @default.
- W2022266275 isParatext "false" @default.
- W2022266275 isRetracted "false" @default.
- W2022266275 magId "2022266275" @default.
- W2022266275 workType "article" @default.