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• W2022268503 abstract "Purpose of review There is recent evidence that immunological priming can start prenatally or in the very early life phase. This review summarizes recent progress in the field of early gut immunology with special attention to factors contributing to the intrauterine and early postnatal development of mucosal immune responses in the gut. Recent findings Development and maturation of the fetal gut immune system occurs under close control of the maternal environment. Examples include maternal antibodies, cytokines, sCD14 molecules and bacterial antigens. Mouse experiments reveal that activated T cells can be detected already at birth in the fetal gut, which are supposed to be activated by signals from the maternal microbial gut flora. Human milk sCD14 is involved in the immunological priming of the developing gut immune system to Gram-negative bacteria and modulates the microbial recognition system of the gut. The development of food allergies is associated with consumption of food components like polyunsaturated fatty acids acting prenatally or in the early postnatal life span as immunomodulators. Summary The new findings highlight the importance of very early life factors for the development of the mucosal immune functions of the gut. Therefore, the gut might be a new target to establish preventive strategies with regard to different immunologic disorders." @default.
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• W2022268503 date "2007-11-01" @default.
• W2022268503 modified "2023-10-16" @default.
• W2022268503 title "Development of mucosal immune function in the intrauterine and early postnatal environment" @default.
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• W2022268503 doi "https://doi.org/10.1097/mog.0b013e3282eeb428" @default.
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