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• W2022268835 endingPage "120" @default.
• W2022268835 startingPage "82" @default.
• W2022268835 abstract "I N 1890 the first Nobellaureate, von Behring, recognized antibodies in serum to diphtheria toxin and introduced passive prophylaxis against the disease. About 60 years later, the potential of this treatment became apparent when Bruton,1 and Good and Varco,z and Barandun et al used gammaglobulin (IgG) to successfully treat infections in children with X-linked infantile agammaglobulinemia. This treatment was quickly extended to other patients as treatment and as prophylaxis. For the next 30 years, most physicians used a standard dose of 100 to 200 mg/kg of IgG every 4 weeks for replacement. This dose did not raise the plasma concentration of IgG to normallevels, but higher doses could not be used because the preparation could only be given by intramuscular injection. In the late 1970s, safe and effective IgG preparations that could be administered intravenously (IV) became available. The ability to give the preparation IV meant that very high doses of IgG could be given, and this led to the recognition that IgG could act as an immune suppressant. As will be discussed, intravenous gammaglobulin (IV IgG) has provided insights into the role of IgG in both physiological and pathological cell clearance. In this review, we will summarize the various preparations of IgG that can be given IV and the efficacy of IV IgG as an replacement and an suppressant, and we will discuss the adverse effects of IV IgG." @default.
• W2022268835 created "2016-06-24" @default.
• W2022268835 creator A5070984120 @default.
• W2022268835 creator A5075115394 @default.
• W2022268835 date "1989-04-01" @default.
• W2022268835 modified "2023-10-15" @default.
• W2022268835 title "Use of Intravenous Gammaglobulin as an Immune Replacement and an Immune Suppressant" @default.
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