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- W2022268992 abstract "The role of olfactory bulb (OB) serotonin [5-hydroxytryptamine (5-HT)] in olfactory learning and memory was tested in the greater short-nosed fruit bat, Cynopterus sphinx (family Pteropodidae). Graded concentrations (25, 40, and 60 μg) of 5,7-dihydroxytryptamine (5,7-DHT) or saline were injected into the OB of bats one day before training to the novel odor. In a behavioral test, 5,7-DHT (60 μg) injected bats made significantly fewer feeding attempts and bouts when compared to saline-injected bats during learning and in the memory test. Subsequent biochemical analysis showed that 5-HT level was effectively depleted in the OB of 5,7-DHT injected bats. To test odor-induced 5-HT mediated changes in 5-HT receptors and second messenger cascade in the OB, we examined the expression of 5-HT receptors and mitogen-activated protein kinase (MAPK)/Erk cascade after training to the novel odor. We found that odor stimulation up-regulated the expression of 5-HT1A receptor, Erk1 and Creb1 mRNA, and phosphorylation of ERK1 and CREB1. Odor stimulation failed to induce expression in 5-HT-depleted bats, which is similar to control bats and significantly low compared to saline-treated bats. Together these data revealed that the level of 5-HT in the OB may regulate olfactory learning and memory in C. sphinx through Erk and CREB." @default.
- W2022268992 created "2016-06-24" @default.
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- W2022268992 creator A5067068998 @default.
- W2022268992 date "2010-09-01" @default.
- W2022268992 modified "2023-09-23" @default.
- W2022268992 title "Role of olfactory bulb serotonin in olfactory learning in the greater short-nosed fruit bat, Cynopterus sphinx (Chiroptera: Pteropodidae)" @default.
- W2022268992 cites W1488313827 @default.
- W2022268992 cites W1493998303 @default.
- W2022268992 cites W1509880157 @default.
- W2022268992 cites W1532762518 @default.
- W2022268992 cites W1615908217 @default.
- W2022268992 cites W1645161804 @default.
- W2022268992 cites W1801803313 @default.
- W2022268992 cites W1937085587 @default.
- W2022268992 cites W1949317008 @default.
- W2022268992 cites W1965771612 @default.
- W2022268992 cites W1969769253 @default.
- W2022268992 cites W1970127965 @default.
- W2022268992 cites W1973707586 @default.
- W2022268992 cites W1974753375 @default.
- W2022268992 cites W1976722549 @default.
- W2022268992 cites W1977125554 @default.
- W2022268992 cites W1977774316 @default.
- W2022268992 cites W1979412265 @default.
- W2022268992 cites W1981593433 @default.
- W2022268992 cites W1982288973 @default.
- W2022268992 cites W1997629431 @default.
- W2022268992 cites W1999782689 @default.
- W2022268992 cites W1999869847 @default.
- W2022268992 cites W2000366839 @default.
- W2022268992 cites W2004739431 @default.
- W2022268992 cites W2005304682 @default.
- W2022268992 cites W2007185003 @default.
- W2022268992 cites W2012749106 @default.
- W2022268992 cites W2013279514 @default.
- W2022268992 cites W2015592781 @default.
- W2022268992 cites W2021617407 @default.
- W2022268992 cites W2022949318 @default.
- W2022268992 cites W2027366290 @default.
- W2022268992 cites W2031067246 @default.
- W2022268992 cites W2036396876 @default.
- W2022268992 cites W2037969014 @default.
- W2022268992 cites W2044126921 @default.
- W2022268992 cites W2045850697 @default.
- W2022268992 cites W2049397044 @default.
- W2022268992 cites W2052853977 @default.
- W2022268992 cites W2052999562 @default.
- W2022268992 cites W2053127867 @default.
- W2022268992 cites W2055829187 @default.
- W2022268992 cites W2058525554 @default.
- W2022268992 cites W2065743565 @default.
- W2022268992 cites W2068412840 @default.
- W2022268992 cites W2074489888 @default.
- W2022268992 cites W2074778634 @default.
- W2022268992 cites W2075993196 @default.
- W2022268992 cites W2079194017 @default.
- W2022268992 cites W2079955486 @default.
- W2022268992 cites W2080308963 @default.
- W2022268992 cites W2082673163 @default.
- W2022268992 cites W2083748369 @default.
- W2022268992 cites W2084318262 @default.
- W2022268992 cites W2085627353 @default.
- W2022268992 cites W2087214325 @default.
- W2022268992 cites W2087970533 @default.
- W2022268992 cites W2088183396 @default.
- W2022268992 cites W2089524009 @default.
- W2022268992 cites W2091845852 @default.
- W2022268992 cites W2094852753 @default.
- W2022268992 cites W2096440470 @default.
- W2022268992 cites W2098974755 @default.
- W2022268992 cites W2104010831 @default.
- W2022268992 cites W2109486415 @default.
- W2022268992 cites W2111735128 @default.
- W2022268992 cites W2113638222 @default.
- W2022268992 cites W2117820491 @default.
- W2022268992 cites W2118977349 @default.
- W2022268992 cites W2120173600 @default.
- W2022268992 cites W2127942125 @default.
- W2022268992 cites W2133083344 @default.
- W2022268992 cites W2146702633 @default.
- W2022268992 cites W2150827333 @default.
- W2022268992 cites W2158276448 @default.
- W2022268992 cites W2161856713 @default.
- W2022268992 cites W2168779635 @default.
- W2022268992 cites W2171532806 @default.
- W2022268992 cites W2271081351 @default.
- W2022268992 cites W4253608535 @default.
- W2022268992 cites W4293247451 @default.
- W2022268992 doi "https://doi.org/10.1016/j.brainres.2010.06.058" @default.
- W2022268992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20599808" @default.
- W2022268992 hasPublicationYear "2010" @default.
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